Detailed information of TA system TA235605

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2196266..2196483
• Replicon: chromosome
• Accession: NZ_CP092052
• Organism: Staphylococcus aureus strain USA300

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: AH5667_RS11010
• Protein ID: WP_001802298.1
• Coordinates: 2196379..2196483 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2196266..2196321 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AH5667_RS10985	2192403..2193068	-	666	WP_001024094.1	SDR family oxidoreductase	-
AH5667_RS10990	2193220..2193540	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
AH5667_RS10995	2193542..2194522	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
AH5667_RS11000	2194788..2195879	+	1092	WP_000495671.1	lytic regulatory protein	-
-	2196266..2196321	+	56	-	-	Antitoxin
AH5667_RS11010	2196379..2196483	-	105	WP_001802298.1	hypothetical protein	Toxin
AH5667_RS11015	2196644..2197127	-	484	Protein_2133	recombinase family protein	-
AH5667_RS11020	2197170..2198306	-	1137	WP_000115564.1	SAP domain-containing protein	-
AH5667_RS11025	2198595..2198687	+	93	WP_001790138.1	hypothetical protein	-
AH5667_RS11035	2199392..2200249	-	858	WP_000370924.1	HAD family hydrolase	-
AH5667_RS11040	2200317..2201099	-	783	WP_000908176.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T235605 WP_001802298.1 NZ_CP092052:c2196483-2196379 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T235605 NZ_LR134311:1126405-1126740 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Nucleotide

• Length: 56 bp

>AT235605 NZ_CP092052:2196266-2196321 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin