Detailed information of TA system TA235599

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2021600..2021899
• Replicon: chromosome
• Accession: NZ_CP092052
• Organism: Staphylococcus aureus strain USA300

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: AH5667_RS10015
• Protein ID: WP_011447039.1
• Coordinates: 2021723..2021899 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2021600..2021655 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AH5667_RS09975	2016931..2017191	+	261	WP_001791826.1	hypothetical protein	-
AH5667_RS09980	2017244..2017594	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
AH5667_RS09985	2018279..2018728	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
AH5667_RS09990	2018823..2019158	-	336	Protein_1933	SH3 domain-containing protein	-
AH5667_RS09995	2019808..2020299	-	492	WP_000919350.1	staphylokinase	-
AH5667_RS10000	2020490..2021245	-	756	WP_000861038.1	CHAP domain-containing protein	-
AH5667_RS10005	2021257..2021511	-	255	WP_000611512.1	phage holin	-
AH5667_RS10010	2021563..2021670	+	108	WP_001791821.1	hypothetical protein	-
-	2021592..2021731	+	140	NuclAT_0	-	-
-	2021592..2021731	+	140	NuclAT_0	-	-
-	2021592..2021731	+	140	NuclAT_0	-	-
-	2021592..2021731	+	140	NuclAT_0	-	-
-	2021600..2021655	+	56	-	-	Antitoxin
AH5667_RS10015	2021723..2021899	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
AH5667_RS10020	2022049..2022345	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
AH5667_RS10025	2022403..2022690	-	288	WP_001040261.1	hypothetical protein	-
AH5667_RS10030	2022737..2022889	-	153	WP_001153681.1	hypothetical protein	-
AH5667_RS10035	2022879..2026664	-	3786	WP_000582165.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2017244..2076211	58967

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T235599 WP_011447039.1 NZ_CP092052:c2021899-2021723 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T235599 NZ_LR134309:c5802564-5802286 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTAGGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin

Nucleotide

• Length: 56 bp

>AT235599 NZ_CP092052:2021600-2021655 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin