Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | HipBST/HipA(toxin) |
| Location | 917658..918921 | Replicon | chromosome |
| Accession | NZ_CP092049 | ||
| Organism | Porphyromonas gingivalis strain W50/BE1 | ||
Toxin (Protein)
| Gene name | HipT | Uniprot ID | Q7MW07 |
| Locus tag | MCS27_RS03905 | Protein ID | WP_010956143.1 |
| Coordinates | 917983..918921 (+) | Length | 313 a.a. |
Antitoxin (Protein)
| Gene name | HipS | Uniprot ID | Q7MW08 |
| Locus tag | MCS27_RS03900 | Protein ID | WP_005874041.1 |
| Coordinates | 917658..917993 (+) | Length | 112 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MCS27_RS03870 (MCS27_03875) | 912991..914072 | + | 1082 | Protein_754 | IS5 family transposase | - |
| MCS27_RS03875 (MCS27_03880) | 914097..914267 | + | 171 | WP_080502141.1 | DNA methylase | - |
| MCS27_RS03880 (MCS27_03885) | 914502..914987 | + | 486 | WP_005874045.1 | HU family DNA-binding protein | - |
| MCS27_RS03885 (MCS27_03890) | 915024..915806 | + | 783 | WP_004584112.1 | DUF4393 domain-containing protein | - |
| MCS27_RS03890 (MCS27_03895) | 916308..917213 | + | 906 | WP_005874039.1 | hypothetical protein | - |
| MCS27_RS03895 (MCS27_03900) | 917437..917661 | + | 225 | WP_005874043.1 | helix-turn-helix transcriptional regulator | - |
| MCS27_RS03900 (MCS27_03905) | 917658..917993 | + | 336 | WP_005874041.1 | HipA N-terminal domain-containing protein | Antitoxin |
| MCS27_RS03905 (MCS27_03910) | 917983..918921 | + | 939 | WP_010956143.1 | HipA domain-containing protein | Toxin |
| MCS27_RS03910 (MCS27_03915) | 918991..919311 | + | 321 | WP_043876418.1 | helix-turn-helix transcriptional regulator | - |
| MCS27_RS03915 (MCS27_03920) | 919413..922847 | + | 3435 | WP_250697966.1 | helicase-related protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 313 a.a. Molecular weight: 36101.60 Da Isoelectric Point: 6.1022
>T235593 WP_010956143.1 NZ_CP092049:917983-918921 [Porphyromonas gingivalis]
MTNRCLYCYEPLVDGEMDYHAKCCRKLFGTPQAPILPYTSSEVRALADEVVRSQTTVTGVQPKLSLDFDQMSNSPKRFTI
VGLWGRFILKPQTERYSHLPELEDVSMHLAEIAKIETVPHGLMRFSDGELCYITRRIDRTGQGEKLPMEDMCQLSERLTE
YKYKGSHEQVAKLISKYSSVPKLDLVKYWEQVLFSWLIGNADMHLKNYSLYAPEGNEYQLTPAYDLLSTALVIPEDTEEL
ALTLCGKKRKLTRQHFLEAMTASGLDEKVCDNIFARFQHILPEWEACIRQSFLPTEMQRQYIEFILLKFSQI
MTNRCLYCYEPLVDGEMDYHAKCCRKLFGTPQAPILPYTSSEVRALADEVVRSQTTVTGVQPKLSLDFDQMSNSPKRFTI
VGLWGRFILKPQTERYSHLPELEDVSMHLAEIAKIETVPHGLMRFSDGELCYITRRIDRTGQGEKLPMEDMCQLSERLTE
YKYKGSHEQVAKLISKYSSVPKLDLVKYWEQVLFSWLIGNADMHLKNYSLYAPEGNEYQLTPAYDLLSTALVIPEDTEEL
ALTLCGKKRKLTRQHFLEAMTASGLDEKVCDNIFARFQHILPEWEACIRQSFLPTEMQRQYIEFILLKFSQI
Download Length: 939 bp
>T235593 NZ_LR134309:2691826-2692401 [Pseudomonas aeruginosa]
ATGAGGCATTCCCCATTCACCGCCGTCTACGACGCGTGCGTTCTATATCCCGCGCCACTGCGGGATTTCCTGATGTGGCT
CGGCCTGTCTGGCCGCTTCCGGGCGCGGTGGAGCCAAGCCATTCATGAGGAGTGGAAACGCAACCTGTTGATCAACCGCC
CCGATCTCACCCGGGTTCAGGTCGACAGGACGTCGGATCTCATGGACAGGGCCATTCCGGACGGCTTGGTGGAGGGCTAC
GAAGCGCTCGTGGCAGGCCTGACATTACCCGATCCGAATGATCGGCACGTCCTGGCTGCGGCGATTCGCTGCGGTGCGAG
CGTGATTGTGACGTTCAACGAACGTGATTTCCCGAACGATCTGCTGGCTCCGTACGGCATCGAATCGCAGCACCCCGATG
AGTTTGTGGACAACCTGCTGGATCTGGATGCGGCCGCCGTAGTGTCGGCTGCGCAGCGCCAGCGTGCCCAACTCAAGCAT
CCGCCGATCGATGTGGACCGCTATCTCGAAATCCTGCTGCGCCAAGGCCTTGTGCAAACGACCAAGGTGCTGGCGACCTA
TCGCACCATTCTCTGA
ATGAGGCATTCCCCATTCACCGCCGTCTACGACGCGTGCGTTCTATATCCCGCGCCACTGCGGGATTTCCTGATGTGGCT
CGGCCTGTCTGGCCGCTTCCGGGCGCGGTGGAGCCAAGCCATTCATGAGGAGTGGAAACGCAACCTGTTGATCAACCGCC
CCGATCTCACCCGGGTTCAGGTCGACAGGACGTCGGATCTCATGGACAGGGCCATTCCGGACGGCTTGGTGGAGGGCTAC
GAAGCGCTCGTGGCAGGCCTGACATTACCCGATCCGAATGATCGGCACGTCCTGGCTGCGGCGATTCGCTGCGGTGCGAG
CGTGATTGTGACGTTCAACGAACGTGATTTCCCGAACGATCTGCTGGCTCCGTACGGCATCGAATCGCAGCACCCCGATG
AGTTTGTGGACAACCTGCTGGATCTGGATGCGGCCGCCGTAGTGTCGGCTGCGCAGCGCCAGCGTGCCCAACTCAAGCAT
CCGCCGATCGATGTGGACCGCTATCTCGAAATCCTGCTGCGCCAAGGCCTTGTGCAAACGACCAAGGTGCTGGCGACCTA
TCGCACCATTCTCTGA
Antitoxin
Download Length: 112 a.a. Molecular weight: 12679.49 Da Isoelectric Point: 4.1551
>AT235593 WP_005874041.1 NZ_CP092049:917658-917993 [Porphyromonas gingivalis]
MKQAIVYWKTLKAGILTESDEGYSFAYDKDYLTMPEAQGISLTMPLREEPFQSNMLHPFFDGLIPEGWLLDIAQKNWKID
SRDRMALLLACCRDCIGAVSIEPLNTTEDDE
MKQAIVYWKTLKAGILTESDEGYSFAYDKDYLTMPEAQGISLTMPLREEPFQSNMLHPFFDGLIPEGWLLDIAQKNWKID
SRDRMALLLACCRDCIGAVSIEPLNTTEDDE
Download Length: 336 bp
>AT235593 NZ_LR134309:2691359-2691829 [Pseudomonas aeruginosa]
ATGACCACCGCCACTGCCCAATCCAAGATGACCCTTCCCGCCGCGGGAGAGGTTAAGGCAGCCGTCCAGGGTCAACGTGC
CTTGGCGGCTTACCTCGCAACCCAGTTCGAGACGCAGCACATCCAGATCTTTGATGACCACAAACAGGCTCATCAGGTGG
AACTGCCTACCTCGGCTTTACGCCTGCTGGTCGACATCCTGGCCGAGTTGGCCGATGGCAATGCAGTAAAGGTGGTGCCC
GTCCATGCAGAGCTGACGACCCAAGAGGCGGCGGACTTGCTCAACGTGTCCCGTCCCCATTTCGTCAAGCTGCTAGAAGA
TGGGGTGTTGGCATTTCATCGCACCGGCAAGCACCGCAGGGTGAGGTTCGCCGATCTGATGCAGTACAAGGAAGCGCGCG
AGCGCGCCAGTGAGCAGGCGATGGCCGAACTCGCTCAGCAGTCGCAAGAGTTGGGAATGGGATACGAATGA
ATGACCACCGCCACTGCCCAATCCAAGATGACCCTTCCCGCCGCGGGAGAGGTTAAGGCAGCCGTCCAGGGTCAACGTGC
CTTGGCGGCTTACCTCGCAACCCAGTTCGAGACGCAGCACATCCAGATCTTTGATGACCACAAACAGGCTCATCAGGTGG
AACTGCCTACCTCGGCTTTACGCCTGCTGGTCGACATCCTGGCCGAGTTGGCCGATGGCAATGCAGTAAAGGTGGTGCCC
GTCCATGCAGAGCTGACGACCCAAGAGGCGGCGGACTTGCTCAACGTGTCCCGTCCCCATTTCGTCAAGCTGCTAGAAGA
TGGGGTGTTGGCATTTCATCGCACCGGCAAGCACCGCAGGGTGAGGTTCGCCGATCTGATGCAGTACAAGGAAGCGCGCG
AGCGCGCCAGTGAGCAGGCGATGGCCGAACTCGCTCAGCAGTCGCAAGAGTTGGGAATGGGATACGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|