Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1206435..1207084 Replicon chromosome
Accession NZ_CP092042
Organism Enterobacter cloacae isolate AVS0889

Toxin (Protein)


Gene name higB Uniprot ID A0A5E1A383
Locus tag MBA36_RS05645 Protein ID WP_013097692.1
Coordinates 1206722..1207084 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A5E1A3P3
Locus tag MBA36_RS05640 Protein ID WP_013097693.1
Coordinates 1206435..1206734 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MBA36_RS05630 (MBA36_05630) 1202845..1204818 + 1974 WP_238518460.1 PhoX family phosphatase -
MBA36_RS05635 (MBA36_05635) 1204921..1206309 + 1389 WP_013097694.1 phenylalanine transporter -
MBA36_RS05640 (MBA36_05640) 1206435..1206734 - 300 WP_013097693.1 helix-turn-helix transcriptional regulator Antitoxin
MBA36_RS05645 (MBA36_05645) 1206722..1207084 - 363 WP_013097692.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MBA36_RS05650 (MBA36_05650) 1207289..1208527 + 1239 WP_013097691.1 MFS transporter -
MBA36_RS05655 (MBA36_05655) 1208543..1209568 + 1026 WP_013097690.1 sugar phosphate isomerase/epimerase -
MBA36_RS05660 (MBA36_05660) 1209561..1210703 + 1143 WP_013097689.1 Gfo/Idh/MocA family oxidoreductase -
MBA36_RS05665 (MBA36_05665) 1210779..1211750 + 972 WP_013097688.1 LacI family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13994.00 Da        Isoelectric Point: 7.3235

>T235578 WP_013097692.1 NZ_CP092042:c1207084-1206722 [Enterobacter cloacae]
MWNVETTDRFDEWFFEQTTALKEDVLAAMHILSEFGPQLGRPFVDTVKASAFGNMKELRIQHRGNPIRAFFAFDPDRKAI
VLCAGDKTGCNQKRFYKEMIALADVEYHRHLANKEAIWQR

Download         Length: 363 bp

>T235578 NZ_LR134306:4610200-4610556 [Yersinia pseudotuberculosis]
ATGAAACCACGCGCCACAGCGCAGGGTGCATTGCCCGTGCCTGTTATTTATCAGCAACTGCTCGCTTTTCTGCTGGAGCA
CCACTATGGCCTGAGCCTCAACGATACGCCCTATCACGATGAACAGATTATTACACAGCAGATAGAACAAGGGATTTCAG
TCGGCGACACCATCAACACACTGGTTGAGAAATATGCATTAGTGCGAATTGGTCGTAACGGGTTCAGCGCACTGGTACAA
GACCCGATGCTGAGTAAGGGCGATATCGCCCGTGCTCGCCAGGCCGCAGGTCTGTGGCGTGCGCATTTTCCGCCAACGTT
GCTGTACCCAACCGAGTCCCTCAATCCTATTCAATAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10875.62 Da        Isoelectric Point: 8.6152

>AT235578 WP_013097693.1 NZ_CP092042:c1206734-1206435 [Enterobacter cloacae]
MATLKELMAQQSAESQERIAAKVEVMRRIVALNQLREELNISQTELAAAMGVKQPTVAKIEQPGNDPRLSTLKRYVSALG
GELSIDVTLPNGKRIAFEI

Download         Length: 300 bp

>AT235578 NZ_LR134306:4610568-4610900 [Yersinia pseudotuberculosis]
ATGAATAACCACATTACGACTTCCCCAACATGGGGCCTGAAACGTGATATTACGCCGCGGTTAGGGGCCCGACTGGTTCA
GGAGGGAACGCATCTGCATTTTCTGAGCGACAGAGCCCACATTGTCGGCACCTTTTCCCTTGAAGCCACTCAGGTTCTTG
ATGCAGCGTTTCCCGCGCTGATAACCAAACTAGAATCGCAACTGCTGTCCGGAGCGCTGGATCCACGCCGTCAGCAGTGC
CTTACGGTCCGGCACGGGGAATTTGTCTGTGACGCCGATACGCTGGGCAGTCACGGCTATGTCTATATCGCGGTGTATCA
AAAACTGTCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E1A383

Antitoxin

Source ID Structure
AlphaFold DB A0A5E1A3P3

References