Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4647696..4648298 Replicon chromosome
Accession NZ_CP092040
Organism Salmonella enterica subsp. enterica serovar Infantis strain S19

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag MCR19_RS22455 Protein ID WP_001159630.1
Coordinates 4647696..4648007 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MCR19_RS22460 Protein ID WP_000362050.1
Coordinates 4648008..4648298 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MCR19_RS22420 (4642809) 4642809..4643408 + 600 WP_000965698.1 glucose-1-phosphatase -
MCR19_RS22425 (4643402) 4643402..4644274 + 873 WP_000921423.1 virulence factor BrkB family protein -
MCR19_RS22430 (4644271) 4644271..4644708 + 438 WP_023993693.1 D-aminoacyl-tRNA deacylase -
MCR19_RS22435 (4644753) 4644753..4645694 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
MCR19_RS22440 (4645709) 4645709..4646155 - 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
MCR19_RS22445 (4646152) 4646152..4646463 - 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
MCR19_RS22450 (4646549) 4646549..4647478 - 930 WP_021294279.1 alpha/beta hydrolase -
MCR19_RS22455 (4647696) 4647696..4648007 + 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
MCR19_RS22460 (4648008) 4648008..4648298 + 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
MCR19_RS22465 (4648345) 4648345..4649274 - 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
MCR19_RS22470 (4649271) 4649271..4649906 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
MCR19_RS22475 (4649903) 4649903..4650805 - 903 WP_000331361.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T235568 WP_001159630.1 NZ_CP092040:4647696-4648007 [Salmonella enterica subsp. enterica serovar Infantis]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

>T235568 NZ_LR134305:c1898764-1898660 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT235568 WP_000362050.1 NZ_CP092040:4648008-4648298 [Salmonella enterica subsp. enterica serovar Infantis]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp

>AT235568 NZ_LR134305:1898566-1898604 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References