Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 25551..26223 Replicon chromosome
Accession NZ_CP092039
Organism Pectobacterium brasiliense strain 130

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MBA20_RS00115 Protein ID WP_119870773.1
Coordinates 25837..26223 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A433N287
Locus tag MBA20_RS00110 Protein ID WP_010281167.1
Coordinates 25551..25850 (-) Length 100 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MBA20_RS00090 (MBA20_00090) 20816..21793 + 978 WP_119870771.1 nucleoside hydrolase -
MBA20_RS00095 (MBA20_00095) 21793..22770 + 978 WP_010296900.1 ABC transporter permease -
MBA20_RS00100 (MBA20_00100) 22767..23675 + 909 WP_039275990.1 ABC transporter permease -
MBA20_RS00105 (MBA20_00105) 23715..25514 + 1800 WP_119870772.1 ABC transporter ATP-binding protein -
MBA20_RS00110 (MBA20_00110) 25551..25850 - 300 WP_010281167.1 XRE family transcriptional regulator Antitoxin
MBA20_RS00115 (MBA20_00115) 25837..26223 - 387 WP_119870773.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MBA20_RS00120 (MBA20_00120) 26545..27243 + 699 WP_005976717.1 D-galactonate utilization transcriptional regulator DgoR -
MBA20_RS00125 (MBA20_00125) 27240..28136 + 897 WP_119870774.1 2-dehydro-3-deoxygalactonokinase -
MBA20_RS00130 (MBA20_00130) 28120..28737 + 618 WP_010281152.1 2-dehydro-3-deoxy-6-phosphogalactonate aldolase -
MBA20_RS00135 (MBA20_00135) 28734..29882 + 1149 WP_010281150.1 galactonate dehydratase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(19-113)

Antitoxin

(32-80)


Sequences


Toxin        


Download         Length: 129 a.a.        Molecular weight: 14718.77 Da        Isoelectric Point: 5.0357

>T235531 WP_119870773.1 NZ_CP092039:c26223-25837 [Pectobacterium brasiliense]
MEVYRLAWEIVTRALFDTWFDEQTETVQEEVLAHLAILEEDGPQLGRPQVDQIKGSKYKNMKELRVQVGGHPFRTFFAFD
RTRKAIVLCAGDKKGENAKLFYERMIKIADAEFASHLISPEVKEDGDA

Download         Length: 387 bp

>T235531 NZ_LR134300:1222802-1223377 [Pseudomonas fluorescens]
ATGAGGCATTCCCCATTCACCGCCGTCTACGACGCGTGCGTTCTATATCCCGCGCCACTGCGGGATTTCCTGATGTGGCT
CGGCCTGTCTGGCCGCTTCCGGGCGCGGTGGAGCCAAGCCATTCATGAGGAGTGGAAACGCAACCTGTTGATCAACCGCC
CCGATCTCACCCGGGTTCAGGTCGACAGGACGTCGGATCTCATGGACCGGGCAATTCCGGACGGCTTGGTGGAGGGCTAC
GAAGCGCTCGTGGCAGGCCTGACATTGCCCGATCCGGACGACCGGCACGTCCTGGCTGCGGCGATTCGCTGCGGTGCGAG
CGTGATTGTGACGTTCAACGAACGGGATTTCCCGAACGATCTGCTGGCTCCGTACGGCATCGAATCGCAGCACCCCGATG
AGTTTGTGGACAACCTACTGGATCTGGACGCGGCCGCCGTGGTGTCGGCTGCGCAGCGCCAGCGTGCCCAACTCAAGCAT
CCGCCGATCGAGGTGGACCGCTATCTCGAAATCCTGCTGCGCCAGGGCCTTGTGCAAACGACCAAGGTGCTGGCGACCTA
TCGCACCATTCTCTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11048.08 Da        Isoelectric Point: 10.6442

>AT235531 WP_010281167.1 NZ_CP092039:c25850-25551 [Pectobacterium brasiliense]
MATLKEMMAKRSPESRARIEARTAEIRQEITLAKLREELNMSQTQLALALGVKQPSIVKMEKVENDPKLSTLKRYVTALG
GKLTLDVTLPDGKRIALTL

Download         Length: 300 bp

>AT235531 NZ_LR134300:1222335-1222805 [Pseudomonas fluorescens]
ATGACCACCGCCACTGCCCAATCCAAGATGACCCTTCCCGCCGCGGGAGAGGTGAAGGCAGCCGTCCAGGGTCAACGTGC
CTTGGCGGCTTACCTCGCAACCCAGTTCGAGACGCAGCACATCCAGATCTTTGATGACCACAAACAGGCTCATCAGGTGG
AACTGCCTACCTCGGCTTTACGCCTGCTGGTCGACATCCTGGCCGAGTTGGCCGATGGCAATGCAGTAAAGGTGGTGCCC
GTCCATGCAGAGCTGACGACCCAAGAGGCGGCGGACTTGCTCAACGTGTCCCGTCCCCATTTCGTCAAGCTGCTCGAAGA
TGGGGTGTTGGCATTTCATCGCACCGGCAAGCACCGCAGGGTGAGGTTCGCCGATCTGATGCAGTACAAGGAAGCGCGCG
AGCGCGCCAGTGAGCAGGCGATGGCCGAACTCGCTCAGCAGTCGCAAGAGTTGGGAATGGGATACGAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A433N287

References