Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 3323035..3323656 Replicon chromosome
Accession NZ_CP092038
Organism Legionella pneumophila strain 11052018-5

Toxin (Protein)


Gene name higB Uniprot ID Q5ZRG7
Locus tag MBG98_RS14875 Protein ID WP_010948600.1
Coordinates 3323435..3323656 (-) Length 74 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MBG98_RS14870 Protein ID WP_010948599.1
Coordinates 3323035..3323325 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MBG98_RS14855 (MBG98_14855) 3319096..3320583 + 1488 WP_010948597.1 lpg2912 family Dot/Icm T4SS effector -
MBG98_RS14860 (MBG98_14860) 3320745..3322187 - 1443 WP_010948598.1 ATP-binding protein -
MBG98_RS14865 (MBG98_14865) 3322555..3322746 + 192 WP_014327021.1 hypothetical protein -
MBG98_RS15415 3322736..3322867 - 132 WP_015443889.1 hypothetical protein -
MBG98_RS14870 (MBG98_14870) 3323035..3323325 - 291 WP_010948599.1 helix-turn-helix domain-containing protein Antitoxin
MBG98_RS14875 (MBG98_14875) 3323435..3323656 - 222 WP_010948600.1 hypothetical protein Toxin
MBG98_RS14880 (MBG98_14880) 3323861..3324364 - 504 WP_015443887.1 hypothetical protein -
MBG98_RS14885 (MBG98_14885) 3324474..3325520 - 1047 WP_010948602.1 FAD-dependent oxidoreductase -
MBG98_RS14890 (MBG98_14890) 3325824..3326786 - 963 WP_015443886.1 lytic murein transglycosylase -
MBG98_RS14895 (MBG98_14895) 3327316..3328494 + 1179 WP_010948604.1 serine hydrolase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(37-88)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8288.46 Da        Isoelectric Point: 3.7468

>T235530 WP_010948600.1 NZ_CP092038:c3323656-3323435 [Legionella pneumophila]
MIFIETPIFTEDVKELLSDEEYAEFQEYLADNPLAGDVIQQTGKLANWQTAKSSMVISRQMGSEAVLELFIIM

Download         Length: 222 bp

>T235530 NZ_LR134300:686898-687485 [Pseudomonas fluorescens]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGTGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAGTTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGCGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.68 Da        Isoelectric Point: 8.0670

>AT235530 WP_010948599.1 NZ_CP092038:c3323325-3323035 [Legionella pneumophila]
MDKKLFERLYESMTQMNEIIDGERVPSREFVVDAVHVKEIRKKTGLTQEKFCHLIDVSIGTLRNWEQGRREPTGPAKALL
RAINKDPEHVLAALAG

Download         Length: 291 bp

>AT235530 NZ_LR134300:687552-688406 [Pseudomonas fluorescens]
GTGCCGGACGAGACGAGCGGAGAACACACGCATTTCTGGCGCGCCGCCGAACTGGGCGGCGTCGAACTGCTGCACGCGCG
CTATGTGGAGCAGCGCTTCGCGCCGCACGTGCACAGCAGCTTCGCCCTGGTCATCATCGAGCAGGGCGCGCAGCGCTTCC
GCCATCGTGGCGGCGAGCACCTGGCCCCGCTGGGCAGCATGGTGCTGATCAACCCCGACGAAGTGCACACCGGCTCCAAG
GCCCATGATGCCGGTTGGCTCTATCGCGGCTACTACCCGGAAATGGAACAGATCGACGGGATTCTCGACGAGCTGGAAAT
CCATCATGGCGGCGTGCCGCGTTTCGCCGACAGCGTGATCCACGACCAGCCCCTGGCACGCGCCTTCGTCCACTTGCACC
GCCTGCTGGCCGAGCATGCCGGCAGCCTGGAAACCCAGACCCGCTGGCGCGAGACGATGCTCGCCCTGTTCCGTCGCCAC
GCCCGCCTGCCAGAAGCGCCGAAGGCCGGGCAGGAGCCGTTGGCGGTGGCCCGCGCCCGCGAACTGCTGGCGGCGCGGTT
GCTCGATCCGCCTTCTCTGGAGGAACTGGCGGCGGCGGTCAATCTGTCCCCGTTCCATTTTGCCCGGGTCTTCCGTCGCG
CCACCGGCATGCCGCCCCACGCCTGGCTCAGACAGCGCCGCCTGGAGCAGGCCAGGGCACTGCTCAAGAGCGGCCGGGCG
CCGCTGGAGGTGGCCCTGGAGCTGGGCTTCGCCGACCAGAGCCACCTCGGTCGCCAGTTCAAGCAGGCCTACGGGGTGGC
ACCGGGTGAATACCGCTCGGCCTGCGCGCGCTCGTCCTTGACGACATACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q5ZRG7

Antitoxin

Source ID Structure

References