Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2856884..2857577 Replicon chromosome
Accession NZ_CP092037
Organism Escherichia coli strain MG1655-377GD

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag MBA16_RS14205 Protein ID WP_000415584.1
Coordinates 2857281..2857577 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag MBA16_RS14200 Protein ID WP_000650107.1
Coordinates 2856884..2857279 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MBA16_RS14190 (2852748) 2852748..2855006 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
MBA16_RS14195 (2855144) 2855144..2856751 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
MBA16_RS14200 (2856884) 2856884..2857279 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
MBA16_RS14205 (2857281) 2857281..2857577 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
MBA16_RS14210 (2857782) 2857782..2858264 - 483 WP_000183505.1 GyrI-like domain-containing protein -
MBA16_RS14215 (2858317) 2858317..2858709 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
MBA16_RS14220 (2858861) 2858861..2859520 + 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
MBA16_RS14225 (2859517) 2859517..2860866 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
MBA16_RS14230 (2860912) 2860912..2861244 - 333 WP_000917684.1 DUF2645 family protein -
MBA16_RS14235 (2861563) 2861563..2862144 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
MBA16_RS14240 (2862175) 2862175..2862489 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T235524 WP_000415584.1 NZ_CP092037:c2857577-2857281 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T235524 NZ_LR134299:1908882-1909178 [Pseudomonas putida]
ATGGAAAAGAGAATGCCTCATTGCCCGCTGGAGCGGGTAAAAGCCCTGGCTGCGGCAAGGCGAATCCGCCCTACGGGTGC
TGCATTGAAAGGCGCCAAGGCGCTGGGAATGGATTTTCCGGGCATGCTTGAGGTGATCACCAGCTTGAAGCGCACTGATT
TCTACAAGAGCATGACCAGCCATATTGACCACCGGGTTTGGCAGGATGTGTATCGCCCGCTTACAGCAATTGGGTACGTT
TATTTGAAATTGTCCGTGGTAGACGACGTGCTCATCGTGTCTTTCAAGGAGTTGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT235524 WP_000650107.1 NZ_CP092037:c2857279-2856884 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT235524 NZ_LR134299:1909181-1909582 [Pseudomonas putida]
ATGAGATGTCCAATATGCGGCGGCTCGGAGCTTGCACCTGACATTCAGGGCATGCCCTATAGCTACAAAGGCGAGATGAC
AGTGATTCCTGAGGTAAGTGGCGATTACTGCTCCGCATGTGGTGAATGTGTACTGAGTCATGATGAAGCCATGCGCGTCA
GTCACTTGATGACGGCATTCGAGCGCCAGGTCAACGCAAATGTTGTGGATCCTTCCTTTATTGCCTCCATACGCAGAAAG
TTCGACCTCGACCAGCGTGAAGCGGGGGAAATCTTCGGTGGTGGGGTCAATGCGTTCTCCCGTTATGAAAACGGCAAGAC
CACCCCGCCAGTGGCGTTGGTGAAACTGCTCAAGCTGCTGGATCGCCATCCAGAACTCTTTGAGGAAGTGCGTACTGCCT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References