Detailed information of TA system TA235423

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4579599..4580201
• Replicon: chromosome
• Accession: NZ_CP091999
• Organism: Salmonella enterica subsp. enterica serovar Kentucky strain N16-1393

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A603E470
• Locus tag: MA802_RS22070
• Protein ID: WP_023138876.1
• Coordinates: 4579890..4580201 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: MA802_RS22065
• Protein ID: WP_000362052.1
• Coordinates: 4579599..4579889 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MA802_RS22050 (4577092)	4577092..4577994	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
MA802_RS22055 (4577991)	4577991..4578626	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
MA802_RS22060 (4578623)	4578623..4579552	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
MA802_RS22065 (4579599)	4579599..4579889	-	291	WP_000362052.1	DNA-binding transcriptional regulator	Antitoxin
MA802_RS22070 (4579890)	4579890..4580201	-	312	WP_023138876.1	hypothetical protein	Toxin
MA802_RS22075 (4580419)	4580419..4581348	+	930	WP_001127698.1	alpha/beta hydrolase	-
MA802_RS22080 (4581434)	4581434..4581745	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
MA802_RS22085 (4581742)	4581742..4582188	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
MA802_RS22090 (4582203)	4582203..4583144	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
MA802_RS22095 (4583189)	4583189..4583626	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
MA802_RS22100 (4583623)	4583623..4584495	-	873	WP_000921423.1	virulence factor BrkB family protein	-
MA802_RS22105 (4584489)	4584489..4585088	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-74)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12356.30 Da
• Isoelectric Point: 9.4460

>T235423 WP_023138876.1 NZ_CP091999:c4580201-4579890 [Salmonella enterica subsp. enterica serovar Kentucky]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T235423 NZ_LR134263:1042359-1042520 [Staphylococcus delphini]
ATGAAAGACGAACAAAAGCATTATGACAATGAAATGGTTGATAGTTTTGATGATGTCGTGGAGCTCGGGAAAGAAATGGA
ACAAATTTCTGAAGCGAACGATGAAGAGAAACTCAATCAATCCCATGATTCAAAAGTGCGTTTTGATAAAGACACAAAAT
AG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10970.65 Da
• Isoelectric Point: 11.0303

>AT235423 WP_000362052.1 NZ_CP091999:c4579889-4579599 [Salmonella enterica subsp. enterica serovar Kentucky]
MDKVLFERLTQSMSQMNEIIEGTRKPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT235423 NZ_LR134263:1041739-1042338 [Staphylococcus delphini]
ATGGCAATGAATTTTAAAGTATTTAAAGATGCAGAAACAGCAGCAACTTTCACAGCAGATATCTTAAGAAAACAGTTAAA
TAACAATCCGACATCGATTGTAGGGTTTCATTTGAATCAAGAAGAAGCACCTGTATTAGATGCATTAAAAAAAGATGTCG
ATCGTCATAGCGTTGATTTCAGTCAAATTCATGTATTGGATTACGACGCGCAACAATCATATTATCAAGCATTAGGTGTC
CCAGAAAAACAAATTCACCACGTACCAGAAGATGAAAAAGTGGAAGCATTTATTAAACATCATGCAAAAACAAAAGATAA
TAAAGGTAAATTGACACTACAAGTCGTGACTATCGATACAGAAGGTCAAATCGGTATTCCTATGAATGACGCCTTATTAC
CAGCGCGTGAAATTATTGTTGTCGTGACAGGTGCAGCGAAAGCAGAACAAGTGAAGAAATTATACGAAGAAAACGGGAAT
ACAACATTTATTCCTTCAGCATTAAAATCACATCGTATGGTAACTGTTGTCCTTGATGAAGTAGCTGCACAAGGTTTACC
TGAAGATGTGCGCAATTACTTTACTTCACTGTACGCATAA

Structures

Toxin

• AlphaFold DB: A0A603E470