Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4457589..4458343 Replicon chromosome
Accession NZ_CP091998
Organism Salmonella enterica subsp. enterica serovar Kentucky strain N18-2092

Toxin (Protein)


Gene name higB Uniprot ID B5F003
Locus tag MA840_RS21645 Protein ID WP_000558166.1
Coordinates 4457589..4457900 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MA840_RS21650 Protein ID WP_001259011.1
Coordinates 4457897..4458343 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MA840_RS21615 (4453247) 4453247..4454149 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
MA840_RS21620 (4454146) 4454146..4454781 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
MA840_RS21625 (4454778) 4454778..4455707 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
MA840_RS21630 (4455754) 4455754..4456044 - 291 WP_000362052.1 DNA-binding transcriptional regulator -
MA840_RS21635 (4456045) 4456045..4456356 - 312 WP_023138876.1 hypothetical protein -
MA840_RS21640 (4456574) 4456574..4457503 + 930 WP_001127698.1 alpha/beta hydrolase -
MA840_RS21645 (4457589) 4457589..4457900 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin Toxin
MA840_RS21650 (4457897) 4457897..4458343 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
MA840_RS21655 (4458358) 4458358..4459299 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
MA840_RS21660 (4459344) 4459344..4459781 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
MA840_RS21665 (4459778) 4459778..4460650 - 873 WP_000921423.1 virulence factor BrkB family protein -
MA840_RS21670 (4460644) 4460644..4461243 - 600 WP_000965695.1 glucose-1-phosphatase -
MA840_RS21675 (4461434) 4461434..4462237 - 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
MA840_RS21680 (4462271) 4462271..4463167 - 897 WP_001520529.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12432.40 Da        Isoelectric Point: 9.5334

>T235402 WP_000558166.1 NZ_CP091998:4457589-4457900 [Salmonella enterica subsp. enterica serovar Kentucky]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Download         Length: 312 bp

>T235402 NZ_LR134248:213549-213656 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16734.08 Da        Isoelectric Point: 6.6451

>AT235402 WP_001259011.1 NZ_CP091998:4457897-4458343 [Salmonella enterica subsp. enterica serovar Kentucky]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT235402 NZ_LR134248:c213492-213435 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9ME90

Antitoxin

Source ID Structure

References