Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 15129..15387 Replicon chromosome
Accession NC_011993
Organism Escherichia coli LF82

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag LF82_RS00075 Protein ID WP_000809168.1
Coordinates 15129..15281 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 15330..15387 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LF82_RS00055 10374..11087 - 714 WP_001102393.1 acidic protein MsyB -
LF82_RS00060 11113..11517 - 405 WP_000843689.1 DUF2541 family protein -
LF82_RS00065 11889..13805 + 1917 WP_000516135.1 molecular chaperone DnaK -
LF82_RS00070 13894..15024 + 1131 WP_001118464.1 molecular chaperone DnaJ -
LF82_RS00075 15129..15281 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 15330..15387 + 58 - - Antitoxin
LF82_RS00080 15896..16657 + 762 WP_001274832.1 hypothetical protein -
LF82_RS00085 16677..18170 + 1494 WP_001443162.1 sulfatase-like hydrolase/transferase -
LF82_RS00090 18299..19558 + 1260 WP_000494928.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T23539 WP_000809168.1 NC_011993:c15281-15129 [Escherichia coli LF82]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T23539 NC_011993:c15281-15129 [Escherichia coli LF82]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT23539 NC_011993:15330-15387 [Escherichia coli LF82]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References