Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE(toxin)
Location 4273658..4274283 Replicon chromosome
Accession NZ_CP091977
Organism Aromatoleum aromaticum strain pCyN1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag L8M16_RS20435 Protein ID WP_041645992.1
Coordinates 4273942..4274283 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag L8M16_RS20430 Protein ID WP_011237352.1
Coordinates 4273658..4273945 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L8M16_RS20395 4269130..4269573 - 444 WP_251199521.1 toprim domain-containing protein -
L8M16_RS20400 4269570..4270199 - 630 WP_248280551.1 primase-helicase zinc-binding domain-containing protein -
L8M16_RS20405 4270192..4271721 - 1530 WP_168954139.1 DEAD/DEAH box helicase -
L8M16_RS20410 4271718..4272296 - 579 WP_168954138.1 YdaU family protein -
L8M16_RS20415 4272293..4272730 - 438 WP_168954137.1 hypothetical protein -
L8M16_RS20420 4272730..4272924 - 195 WP_041645990.1 hypothetical protein -
L8M16_RS20425 4272997..4273557 - 561 WP_011237351.1 hypothetical protein -
L8M16_RS20430 4273658..4273945 - 288 WP_011237352.1 helix-turn-helix domain-containing protein Antitoxin
L8M16_RS20435 4273942..4274283 - 342 WP_041645992.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L8M16_RS20440 4274312..4275673 - 1362 WP_011237354.1 integrase family protein -
L8M16_RS20445 4276183..4276686 - 504 WP_011237355.1 hypothetical protein -
L8M16_RS20450 4276984..4277484 - 501 WP_168954136.1 flavin reductase family protein -
L8M16_RS20455 4277603..4278670 + 1068 WP_011237357.1 A/G-specific adenine glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(36-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-79)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12790.72 Da        Isoelectric Point: 10.1223

>T235322 WP_041645992.1 NZ_CP091977:c4274283-4273942 [Aromatoleum aromaticum]
MQTVAELPEYIRTADKLLSAEERQDIIRYLAEHPKDGDLMEGTGGVRKLRWRRGGQGKSGGVRVIYYFHDDAMPLYLLTL
FAKGDRANLSKAERNELAGLTTLLVKAWRGKRA

Download         Length: 342 bp

>T235322 NZ_LR134237:4063483-4063860 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCTTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCAG
CAACTACAGAATGGTGAACGACATCATCCGGGGTGAACATTCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10427.97 Da        Isoelectric Point: 11.3253

>AT235322 WP_011237352.1 NZ_CP091977:c4273945-4273658 [Aromatoleum aromaticum]
MSTAFDSIKRGLMEAIDHAEGRAPATRVHRPRPVDVKALRAKVGMTQEQFAARFGFSTATLRHWERGDRTPHGPALVLLN
VIDRNPAAVIEALSA

Download         Length: 288 bp

>AT235322 NZ_LR134237:4063062-4063436 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCATCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References