Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4210834..4211422 Replicon chromosome
Accession NZ_CP091977
Organism Aromatoleum aromaticum strain pCyN1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag L8M16_RS20075 Protein ID WP_041645963.1
Coordinates 4210834..4211112 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag L8M16_RS20080 Protein ID WP_011237269.1
Coordinates 4211123..4211422 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L8M16_RS20050 4206422..4207510 - 1089 WP_011254940.1 IS21-like element ISAzo17 family transposase -
L8M16_RS20055 4207463..4208044 + 582 WP_251199518.1 hypothetical protein -
L8M16_RS20060 4208046..4208795 - 750 WP_011237264.1 TIGR03747 family integrating conjugative element membrane protein -
L8M16_RS20065 4208792..4209490 - 699 Protein_3947 TraM recognition domain-containing protein -
L8M16_RS20900 4209699..4209824 - 126 WP_256469880.1 hypothetical protein -
L8M16_RS20070 4210050..4210739 + 690 WP_011237267.1 transposase -
L8M16_RS20075 4210834..4211112 + 279 WP_041645963.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L8M16_RS20080 4211123..4211422 + 300 WP_011237269.1 HigA family addiction module antitoxin Antitoxin
L8M16_RS20085 4211608..4212300 + 693 WP_011237270.1 SDR family oxidoreductase -
L8M16_RS20090 4212386..4213057 + 672 WP_157866591.1 transglutaminase family protein -
L8M16_RS20095 4213201..4215204 - 2004 WP_168953919.1 ATP-binding cassette domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4183176..4216735 33559
- flank IS/Tn - - 4215248..4216471 1223


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10236.72 Da        Isoelectric Point: 9.7361

>T235321 WP_041645963.1 NZ_CP091977:4210834-4211112 [Aromatoleum aromaticum]
MIKSFRHKGIEAFFRTGSKAGITATHVGRLARQLALLNEATHPGHMDVPGWKLHPLAGSLKGHWAVLVSGNWRLTFAFEG
EDAVLVDYQDYH

Download         Length: 279 bp

>T235321 NZ_LR134237:3759104-3759322 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10910.63 Da        Isoelectric Point: 10.5822

>AT235321 WP_011237269.1 NZ_CP091977:4211123-4211422 [Aromatoleum aromaticum]
MAPMYNPPHPGETLREDILPALGLTVSEAARQLGISRVQLSRVLHGRAPVSPDLALRLEQWLSGPTADIWLRMQIAYDLW
QARHGGSLPRVAPAQRKAA

Download         Length: 300 bp

>AT235321 NZ_LR134237:3758704-3759078 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References