Detailed information of TA system TA235313

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-YefM
• Location: 2214267..2214769
• Replicon: chromosome
• Accession: NZ_CP091977
• Organism: Aromatoleum aromaticum strain pCyN1

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: L8M16_RS10695
• Protein ID: WP_011239255.1
• Coordinates: 2214267..2214533 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: L8M16_RS10700
• Protein ID: WP_011239256.1
• Coordinates: 2214527..2214769 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L8M16_RS10660	2209373..2210530	+	1158	WP_168954652.1	PQQ-dependent sugar dehydrogenase	-
L8M16_RS10665	2210615..2210974	+	360	WP_041646544.1	MbcA/ParS/Xre antitoxin family protein	-
L8M16_RS10670	2210971..2211159	+	189	WP_211160077.1	hypothetical protein	-
L8M16_RS10675	2211234..2211539	+	306	WP_011236214.1	hypothetical protein	-
L8M16_RS10680	2211539..2211898	+	360	WP_011236213.1	IS66 family insertion sequence element accessory protein TnpB	-
L8M16_RS10685	2211927..2213543	+	1617	WP_011236212.1	IS66-like element ISAzo19 family transposase	-
L8M16_RS10690	2213483..2214154	+	672	WP_251199450.1	RES family NAD+ phosphorylase	-
L8M16_RS10695	2214267..2214533	-	267	WP_011239255.1	Txe/YoeB family addiction module toxin	Toxin
L8M16_RS10700	2214527..2214769	-	243	WP_011239256.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
L8M16_RS10705	2215329..2216165	-	837	WP_211160114.1	hypothetical protein	-
L8M16_RS10710	2216238..2217194	-	957	WP_251199599.1	thermonuclease family protein	-
L8M16_RS10715	2217565..2218101	-	537	WP_248280670.1	hypothetical protein	-
L8M16_RS10720	2218128..2218613	+	486	WP_168954971.1	acyl-CoA thioesterase	-
L8M16_RS10725	2218610..2218840	+	231	WP_168954970.1	VF530 family protein	-
L8M16_RS20870	2218982..2219104	+	123	WP_256469848.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10065.71 Da
• Isoelectric Point: 10.0262

>T235313 WP_011239255.1 NZ_CP091977:c2214533-2214267 [Aromatoleum aromaticum]
VVSWEVVYARQALKDAKKLAASGLKPKAQELLAVLADDPFKNPPPFEKLVGDLAGAYSRRINIQHRIVYEVFANEKTVRV
LRMWTHYE

Nucleotide

• Length: 267 bp

>T235313 NZ_LR134237:1252153-1252464 [Escherichia coli]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTACACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACGCCAGAAGAAATGCGAACGGCTTTTCCCAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATCACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8858.20 Da
• Isoelectric Point: 5.8020

>AT235313 WP_011239256.1 NZ_CP091977:c2214769-2214527 [Aromatoleum aromaticum]
MNTLTASEARANLYRLIDQTVESHEPIIITGKRNSAVLLSAEDWSAIQETLYLLAVPGMRESIKAGMAEPLAKSSKELKW

Nucleotide

• Length: 243 bp

>AT235313 NZ_LR134237:1252461-1252880 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCTGTT
GGTGTGGCGTTACTTCGCACGCTGATTGATCAACATAATCTGACCTATGCAGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGCCAGATCTTGTCTGGACAACGATCCTTGACGATACCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA