Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 712550..713243 Replicon chromosome
Accession NZ_CP091925
Organism Escherichia coli strain JNQH497

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag KIF99_RS03470 Protein ID WP_000415584.1
Coordinates 712550..712846 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag KIF99_RS03475 Protein ID WP_000650107.1
Coordinates 712848..713243 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIF99_RS03435 (707638) 707638..707952 - 315 WP_000958598.1 putative quinol monooxygenase -
KIF99_RS03440 (707983) 707983..708564 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
KIF99_RS03445 (708883) 708883..709215 + 333 WP_000917684.1 DUF2645 family protein -
KIF99_RS03450 (709261) 709261..710610 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
KIF99_RS03455 (710607) 710607..711266 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
KIF99_RS03460 (711418) 711418..711810 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
KIF99_RS03465 (711863) 711863..712345 + 483 WP_000183505.1 GyrI-like domain-containing protein -
KIF99_RS03470 (712550) 712550..712846 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
KIF99_RS03475 (712848) 712848..713243 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
KIF99_RS03480 (713376) 713376..714983 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
KIF99_RS03485 (715121) 715121..717379 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T235249 WP_000415584.1 NZ_CP091925:712550-712846 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T235249 NZ_LR134231:3375602-3375820 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT235249 WP_000650107.1 NZ_CP091925:712848-713243 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT235249 NZ_LR134231:3375202-3375576 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References