235227

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2648818..2649205 Replicon chromosome
Accession NZ_CP091906
Organism Enterococcus faecalis strain 2-1

Toxin (Protein)


Gene name txpA Uniprot ID A0A1J6YG70
Locus tag L5I26_RS12675 Protein ID WP_002396786.1
Coordinates 2649062..2649205 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2648818..2648951 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5I26_RS12665 2644394..2644498 + 105 WP_021164545.1 putative holin-like toxin -
L5I26_RS12670 2644688..2648467 - 3780 WP_010818049.1 WxL domain-containing protein -
- 2648818..2648951 - 134 - - Antitoxin
L5I26_RS12675 2649062..2649205 + 144 WP_002396786.1 putative holin-like toxin Toxin
L5I26_RS12680 2649399..2652458 - 3060 WP_002398514.1 WxL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5203.19 Da        Isoelectric Point: 8.6626

>T235227 WP_002396786.1 NZ_CP091906:2649062-2649205 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Download         Length: 144 bp

>T235227 NZ_LR134228:2814533-2814640 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 134 bp

>AT235227 NZ_CP091906:c2648951-2648818 [Enterococcus faecalis]
TTGTGCTATAATAGCAATGAAAAGAGAGATATGCTGTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCCGT
TATTATTTAAAAATAACCGTACTTGGTCAAAGTAGACGGTTATTTTTTCTTGTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J6YG70

Antitoxin

Download structure file

References