Detailed information of TA system TA235224

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2648808..2649205
• Replicon: chromosome
• Accession: NZ_CP091906
• Organism: Enterococcus faecalis strain 2-1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A1J6YG70
• Locus tag: L5I26_RS12675
• Protein ID: WP_002396786.1
• Coordinates: 2649062..2649205 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2648808..2648965 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5I26_RS12665	2644394..2644498	+	105	WP_021164545.1	putative holin-like toxin	-
L5I26_RS12670	2644688..2648467	-	3780	WP_010818049.1	WxL domain-containing protein	-
-	2648808..2648965	-	158	-	-	Antitoxin
L5I26_RS12675	2649062..2649205	+	144	WP_002396786.1	putative holin-like toxin	Toxin
L5I26_RS12680	2649399..2652458	-	3060	WP_002398514.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5203.19 Da
• Isoelectric Point: 8.6626

>T235224 WP_002396786.1 NZ_CP091906:2649062-2649205 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Nucleotide

• Length: 144 bp

>T235224 NZ_LR134228:2371424-2371711 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Nucleotide

• Length: 158 bp

>AT235224 NZ_CP091906:c2648965-2648808 [Enterococcus faecalis]
GTTTTTTTAGGTAATTGTGCTATAATAGCAATGAAAAGAGAGATATGCTGTAACATACCTCTCTAGTGTAGAGCCGTTTA
AGACGGTGACCCGTTATTATTTAAAAATAACCGTACTTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTCAGC

Structures

Toxin

• AlphaFold DB: A0A1J6YG70

Antitoxin