Detailed information of TA system TA235221

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2644394..2644686
• Replicon: chromosome
• Accession: NZ_CP091906
• Organism: Enterococcus faecalis strain 2-1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: L5I26_RS12665
• Protein ID: WP_021164545.1
• Coordinates: 2644394..2644498 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2644431..2644686 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5I26_RS12645	2639634..2639849	-	216	WP_002354768.1	zinc ribbon domain-containing protein	-
L5I26_RS12650	2639988..2640980	+	993	WP_002398510.1	biotin--[acetyl-CoA-carboxylase] ligase	-
L5I26_RS12655	2641147..2641785	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
L5I26_RS12660	2642469..2644085	+	1617	WP_002372620.1	phosphatase PAP2/LCP family protein	-
L5I26_RS12665	2644394..2644498	+	105	WP_021164545.1	putative holin-like toxin	Toxin
-	2644431..2644686	-	256	-	-	Antitoxin
L5I26_RS12670	2644688..2648467	-	3780	WP_010818049.1	WxL domain-containing protein	-
L5I26_RS12675	2649062..2649205	+	144	WP_002396786.1	putative holin-like toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-34)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3813.70 Da
• Isoelectric Point: 10.3686

>T235221 WP_021164545.1 NZ_CP091906:2644394-2644498 [Enterococcus faecalis]
MSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 105 bp

>T235221 NZ_LR134228:1909945-1910196 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Nucleotide

• Length: 256 bp

>AT235221 NZ_CP091906:c2644686-2644431 [Enterococcus faecalis]
ATAAAAATGCCCGAGCCTTGAAATAGGAGGCTCAGGCATTTTTTATTGATGGTCTTTTTAGGGTTGTTGTGCTATAATGA
TAAAGAAAAGAGAGATATGCTTCCAACATATCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCGTGTTAATTATTTAAA
AATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCAATCAAAGCA
ATGGTAAACATACCAA

Structures

Antitoxin