Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2991325..2991922 Replicon chromosome
Accession NC_011979
Organism Geobacter daltonii FRC-32

Toxin (Protein)


Gene name graT Uniprot ID B9M1J2
Locus tag GEOB_RS13515 Protein ID WP_012647802.1
Coordinates 2991641..2991922 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GEOB_RS13510 Protein ID WP_012647801.1
Coordinates 2991325..2991630 (-) Length 102 a.a.

Genomic Context

GEOB_RS13475GEOB_RS13480GEOB_RS13485GEOB_RS13490GEOB_RS13495GEOB_RS13500GEOB_RS13505GEOB_RS13520GEOB_RS19970GEOB_RS19820GEOB_RS13510GEOB_RS13515GEOB_RS13530GEOB_RS13535GEOB_RS13540
Location: 2986745..2987449 (705 bp)
Type: Others
Protein ID: WP_012647794.1
Location: 2987446..2988036 (591 bp)
Type: Others
Protein ID: WP_012647795.1
Location: 2988038..2988502 (465 bp)
Type: Others
Protein ID: WP_012647796.1
Location: 2988502..2989089 (588 bp)
Type: Others
Protein ID: WP_012647797.1
Location: 2989207..2990058 (852 bp)
Type: Others
Protein ID: WP_012647798.1
Location: 2990188..2990790 (603 bp)
Type: Others
Protein ID: WP_012647799.1
Location: 2990919..2991215 (297 bp)
Type: Others
Protein ID: WP_012647800.1
Location: 2992000..2992830 (831 bp)
Type: Others
Protein ID: WP_012647803.1
Location: 2992871..2993389 (519 bp)
Type: Others
Protein ID: WP_012647804.1
Location: 2993395..2993682 (288 bp)
Type: Others
Protein ID: Protein_2688
Location: 2991325..2991630 (306 bp)
Type: Antitoxin
Protein ID: WP_012647801.1
Location: 2991641..2991922 (282 bp)
Type: Toxin
Protein ID: WP_012647802.1
Location: 2993898..2994812 (915 bp)
Type: Others
Protein ID: WP_012647806.1
Location: 2994922..2995671 (750 bp)
Type: Others
Protein ID: WP_012647807.1
Location: 2995685..2996191 (507 bp)
Type: Others
Protein ID: WP_012647808.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GEOB_RS134752986745..2987449+705WP_012647794.1DNA lyase-
GEOB_RS134802987446..2988036+591WP_012647795.17-cyano-7-deazaguanine synthase-
GEOB_RS134852988038..2988502+465WP_012647796.1TIR domain-containing protein-
GEOB_RS134902988502..2989089+588WP_012647797.1hypothetical protein-
GEOB_RS134952989207..2990058+852WP_012647798.1hypothetical protein-
GEOB_RS135002990188..2990790+603WP_012647799.1hypothetical protein-
GEOB_RS135052990919..2991215+297WP_012647800.1DUF167 domain-containing protein-
GEOB_RS135102991325..2991630-306WP_012647801.1HigA family addiction module antidote proteinAntitoxin
GEOB_RS135152991641..2991922-282WP_012647802.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GEOB_RS135202992000..2992830+831WP_012647803.1hypothetical protein-
GEOB_RS199702992871..2993389+519WP_012647804.1hypothetical protein-
GEOB_RS198202993395..2993682+288Protein_2688hypothetical protein-
GEOB_RS135302993898..2994812-915WP_012647806.1transporter-
GEOB_RS135352994922..2995671-750WP_012647807.1cytochrome C biogenesis protein CcdA-
GEOB_RS135402995685..2996191-507WP_012647808.1TlpA family protein disulfide reductase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-67)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10829.34 Da        Isoelectric Point: 9.9018

>T23522 WP_012647802.1 NC_011979:c2991922-2991641 [Geobacter daltonii FRC-32]
MIKTFACKETEKLFHGRFSGKLPQDVQRIAQRKLKQIHGATTLDFLRVPPGNRLEQLSGSRTGQWSIRINDQWRICFTWQ
DGNATDVEIVDYH

Download         Length: 282 bp

>T23522 NC_011979:c2991922-2991641 [Geobacter daltonii FRC-32]
ATGATCAAGACGTTTGCCTGTAAAGAGACTGAAAAGCTTTTTCACGGCCGCTTTTCCGGAAAGCTGCCACAGGATGTGCA
GCGTATCGCCCAACGGAAGCTAAAACAGATTCATGGCGCCACTACCCTGGATTTTCTCCGCGTACCACCAGGCAACAGGC
TTGAGCAACTTTCAGGGAGCCGCACCGGCCAGTGGAGCATCCGAATCAACGACCAATGGCGCATCTGTTTTACCTGGCAA
GACGGAAATGCAACGGACGTCGAAATCGTCGATTACCACTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11490.33 Da        Isoelectric Point: 7.8277

>AT23522 WP_012647801.1 NC_011979:c2991630-2991325 [Geobacter daltonii FRC-32]
MIKRDLPPVHPGEILLEDFLKPLNVTRYRLAKSIGVPQRRIDEICAGKRAITADTALRLARFFGTDAQSWMNLQAQYDLE
CAEITLAERIEQEVKPLRNAA

Download         Length: 306 bp

>AT23522 NC_011979:c2991630-2991325 [Geobacter daltonii FRC-32]
ATGATAAAACGCGATCTTCCCCCGGTACATCCTGGAGAAATTCTCCTTGAAGACTTTCTAAAGCCGCTAAACGTTACCCG
CTATAGGCTTGCCAAGTCCATCGGCGTACCCCAACGCCGTATCGATGAAATCTGCGCCGGCAAACGGGCCATCACTGCCG
ACACCGCCTTGCGCCTTGCCCGGTTCTTCGGCACAGACGCCCAAAGCTGGATGAATCTTCAAGCCCAATACGATCTCGAA
TGTGCTGAAATCACTTTGGCTGAGCGAATCGAGCAAGAAGTGAAACCTCTCAGAAATGCAGCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBB9M1J2

Antitoxin

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Source
ID
Structure
No matching records found

References