Detailed information of TA system TA235216

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2565872..2566134
• Replicon: chromosome
• Accession: NZ_CP091906
• Organism: Enterococcus faecalis strain 2-1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: S4BYM2
• Locus tag: L5I26_RS12330
• Protein ID: WP_002392696.1
• Coordinates: 2565991..2566134 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2565872..2566017 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5I26_RS12315	2561287..2564031	+	2745	WP_025189669.1	glycosyl hydrolase family 65 protein	-
L5I26_RS12320	2564046..2564696	+	651	WP_002398182.1	beta-phosphoglucomutase	-
L5I26_RS12325	2565158..2565751	+	594	WP_002398183.1	PBECR4 domain-containing protein	-
-	2565872..2566017	+	146	-	-	Antitoxin
L5I26_RS12330	2565991..2566134	-	144	WP_002392696.1	type I toxin-antitoxin system toxin PepG1	Toxin
L5I26_RS12335	2566366..2567337	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
L5I26_RS12340	2567512..2567949	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
L5I26_RS12345	2568082..2568636	-	555	WP_002354869.1	Maf family protein	-
L5I26_RS12350	2568661..2570793	-	2133	WP_010716772.1	DNA mismatch repair endonuclease MutL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5297.43 Da
• Isoelectric Point: 10.6867

>T235216 WP_002392696.1 NZ_CP091906:c2566134-2565991 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 144 bp

>T235216 NZ_LR134228:c829146-828769 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin

Nucleotide

• Length: 146 bp

>AT235216 NZ_CP091906:2565872-2566017 [Enterococcus faecalis]
TGTGCTATAATGAAAATGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCGATT
TTGTTACAAAAAATAACCGTACTCGATCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAAGCAA

Structures

Toxin

• AlphaFold DB: S4BYM2

Antitoxin