Detailed information of TA system TA235213

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2493931..2494156
• Replicon: chromosome
• Accession: NZ_CP091906
• Organism: Enterococcus faecalis strain 2-1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: L5I26_RS11990
• Protein ID: WP_075551663.1
• Coordinates: 2494055..2494156 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2493931..2494110 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5I26_RS11960	2489147..2490100	-	954	WP_002375576.1	siderophore ABC transporter substrate-binding protein	-
L5I26_RS11965	2490139..2490894	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
L5I26_RS11970	2490891..2491856	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
L5I26_RS11975	2491853..2492800	-	948	WP_010716775.1	iron chelate uptake ABC transporter family permease subunit	-
L5I26_RS11980	2492985..2493437	+	453	WP_002354958.1	YueI family protein	-
L5I26_RS11985	2493622..2493723	-	102	WP_075551663.1	putative holin-like toxin	-
-	2493931..2494110	+	180	-	-	Antitoxin
L5I26_RS11990	2494055..2494156	-	102	WP_075551663.1	putative holin-like toxin	Toxin
L5I26_RS11995	2494346..2496616	-	2271	WP_002398160.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
L5I26_RS12000	2496787..2497287	+	501	WP_002365352.1	cysteine hydrolase family protein	-
L5I26_RS12005	2497590..2498486	+	897	WP_002354953.1	YitT family protein	-
L5I26_RS12010	2498537..2498935	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3599.34 Da
• Isoelectric Point: 4.5869

>T235213 WP_075551663.1 NZ_CP091906:c2494156-2494055 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

>T235213 NZ_LR134228:c629577-629113 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Nucleotide

• Length: 180 bp

>AT235213 NZ_CP091906:2493931-2494110 [Enterococcus faecalis]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGT
TTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACC
GAAAATCAGTAGTGCAACAA

Structures

Antitoxin