Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2898692..2899028 Replicon chromosome
Accession NZ_CP091904
Organism Enterococcus faecalis strain 43-2

Toxin (Protein)


Gene name txpA Uniprot ID E2Z0W4
Locus tag L5I20_RS14410 Protein ID WP_002381035.1
Coordinates 2898692..2898835 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2898979..2899028 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5I20_RS14390 2893810..2894025 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
L5I20_RS14395 2894164..2895156 + 993 WP_002385136.1 biotin--[acetyl-CoA-carboxylase] ligase -
L5I20_RS14400 2895420..2896058 - 639 WP_002378863.1 lytic polysaccharide monooxygenase -
L5I20_RS14405 2896746..2898362 + 1617 WP_002372620.1 phosphatase PAP2/LCP family protein -
L5I20_RS14410 2898692..2898835 + 144 WP_002381035.1 putative holin-like toxin Toxin
- 2898979..2899028 + 50 - - Antitoxin
L5I20_RS14415 2899030..2902026 - 2997 WP_002385134.1 WxL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5202.20 Da        Isoelectric Point: 10.0041

>T235199 WP_002381035.1 NZ_CP091904:2898692-2898835 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Download         Length: 144 bp

>T235199 NZ_LR134227:1954703-1954806 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 50 bp

>AT235199 NZ_CP091904:2898979-2899028 [Enterococcus faecalis]
AATAAAAATGCCCGAGCCTTAGAAAAATAAGAGGCTCGGGCATTTTTATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z6BWH2

Antitoxin

Download structure file

References