Detailed information of TA system TA235181

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): fst-RNAII/Fst(toxin)
• Location: 86771..86985
• Replicon: plasmid p1
• Accession: NZ_CP091902
• Organism: Enterococcus faecalis strain 59

Toxin (Protein)

• Gene name: fst
• Uniprot ID: -
• Locus tag: L5I17_RS15485
• Protein ID: WP_002360667.1
• Coordinates: 86771..86881 (+)
• Length: 37 a.a.

Antitoxin (RNA)

Gene name	RNAII
Locus tag	-
Coordinates	86921..86985 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5I17_RS15445	81856..82227	+	372	WP_238464148.1	transposase	-
L5I17_RS15450	82255..82596	-	342	WP_238464150.1	hypothetical protein	-
L5I17_RS15455	82614..82814	-	201	WP_238464151.1	hypothetical protein	-
L5I17_RS15460	83341..84078	-	738	WP_128888465.1	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B)	-
L5I17_RS15465	84203..84286	-	84	WP_001814874.1	23S rRNA methyltransferase attenuation leader peptide	-
L5I17_RS15470	84845..86173	+	1329	WP_002370254.1	ultraviolet resistance protein UvrA	-
L5I17_RS15475	86170..86520	+	351	WP_002360672.1	hypothetical protein	-
L5I17_RS15480	86477..86689	+	213	WP_002360669.1	hypothetical protein	-
L5I17_RS15485	86771..86881	+	111	WP_002360667.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	86921..86985	-	65	-	-	Antitoxin
L5I17_RS15490	87121..87417	+	297	WP_002369784.1	hypothetical protein	-
L5I17_RS15495	87537..87812	-	276	WP_002369783.1	DNA segregation protein PrgO	-
L5I17_RS15500	87790..88719	-	930	WP_002366009.1	ParA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	aac(6')-aph(2'') / erm(B)	-	1..88965	88965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 37 a.a.
• Molecular weight: 4117.92 Da
• Isoelectric Point: 4.1672

>T235181 WP_002360667.1 NZ_CP091902:86771-86881 [Enterococcus faecalis]
VLFVKDLMSLVIAPIFVGLVLEMISRVLDEEDDNRK

Nucleotide

• Length: 111 bp

>T235181 NZ_LR134226:2609371-2609478 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 65 bp

>AT235181 NZ_CP091902:c86985-86921 [Enterococcus faecalis]
AACGACATTAAATCGTACAAATAACACAAAAAGCAATCCTACGGCGAATAGGATTGCTTTTTTTT

Structures

Antitoxin