Detailed information of TA system TA235167

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2917782..2918045
• Replicon: chromosome
• Accession: NZ_CP091901
• Organism: Enterococcus faecalis strain 59

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: S4BYM2
• Locus tag: L5I17_RS14230
• Protein ID: WP_002392696.1
• Coordinates: 2917902..2918045 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2917782..2917969 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5I17_RS14215	2913243..2915987	+	2745	WP_002406717.1	glycosyl hydrolase family 65 protein	-
L5I17_RS14220	2916002..2916652	+	651	WP_002354875.1	beta-phosphoglucomutase	-
L5I17_RS14225	2917067..2917585	+	519	WP_002354874.1	PBECR4 domain-containing protein	-
-	2917782..2917969	+	188	-	-	Antitoxin
L5I17_RS14230	2917902..2918045	-	144	WP_002392696.1	type I toxin-antitoxin system toxin PepG1	Toxin
L5I17_RS15840	2918453..2918578	-	126	WP_002383214.1	hypothetical protein	-
L5I17_RS14235	2918783..2918989	+	207	WP_224561207.1	CPBP family intramembrane metalloprotease	-
L5I17_RS14240	2919042..2920013	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
L5I17_RS14245	2920188..2920625	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
L5I17_RS14250	2920758..2921312	-	555	WP_002354869.1	Maf family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5297.43 Da
• Isoelectric Point: 10.6867

>T235167 WP_002392696.1 NZ_CP091901:c2918045-2917902 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 144 bp

>T235167 NZ_LR134222:c4445538-4444990 [Escherichia coli]
ATGTCTCATAATTCAGATATCTATAAACTGATCGGAGCGGCCGCAGGTGTTGAAAATGGTCGCTCTGAAGCATCCTTAAA
CTCTACTGACAGTCAAGAGCAGGCTTTTGAATCCGCATTTGAGCCGTCTAATCATGAACGCGATGATGATTCTTCTTCAG
AAAATAAGGCTATTCTGGAGGAAGAAGAGTTTGGTTCTAATACTGGTGCATTGCATGAGTTTATGCAGCAGAACAGAATG
GACAGTCTTCAAGCTCAGCTTGATATGCTCAAATCACAAGTACGGGATAAGATAGCTGACGCAACTGGTAAAGAAATAGA
CAATGAGCTCCGGACAAAAATGGCATCATTCACGGTTTGGTTTATGTCGTGTTGGTGCTTATTCGTTGTCGCAATGTTTA
CATCGTTTCTTATTGCACATGAAGGAAAGGCTCCAGTTGAAGCGATCGTTGCATTACTAGGTACAAGTACAATTAGTATT
GTTGGTTTGGTTGGTTTCGTTGTTAGTGGATTGTTCAAATCAAGAAAAGATAGTGATAAAGAAAAATAA

Antitoxin

Nucleotide

• Length: 188 bp

>AT235167 NZ_CP091901:2917782-2917969 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGCAGAACCGTTTAAGACGGTGACTTTTT
GAATTATTTAAAAATAACCGTACTCGGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGT
GCAATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: S4BYM2

Antitoxin