Detailed information of TA system TA235159

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2843298..2843521
• Replicon: chromosome
• Accession: NZ_CP091901
• Organism: Enterococcus faecalis strain 59

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: L5I17_RS13870
• Protein ID: WP_075551663.1
• Coordinates: 2843420..2843521 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2843298..2843475 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5I17_RS13845	2838945..2839898	-	954	WP_002354964.1	siderophore ABC transporter substrate-binding protein	-
L5I17_RS13850	2839937..2840692	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
L5I17_RS13855	2840689..2841654	-	966	WP_002354961.1	iron chelate uptake ABC transporter family permease subunit	-
L5I17_RS13860	2841651..2842598	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
L5I17_RS13865	2842783..2843235	+	453	WP_002354958.1	YueI family protein	-
-	2843298..2843475	+	178	-	-	Antitoxin
L5I17_RS13870	2843420..2843521	-	102	WP_075551663.1	putative holin-like toxin	Toxin
L5I17_RS13875	2843853..2843954	-	102	WP_075551663.1	putative holin-like toxin	-
L5I17_RS13880	2844144..2846414	-	2271	WP_002354955.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
L5I17_RS13885	2846585..2847085	+	501	WP_002354954.1	cysteine hydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3599.34 Da
• Isoelectric Point: 4.5869

>T235159 WP_075551663.1 NZ_CP091901:c2843521-2843420 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

>T235159 NZ_LR134222:2718389-2718496 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 178 bp

>AT235159 NZ_CP091901:2843298-2843475 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCTTTTATACCAGCGCCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTT
TTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGA
AAATCAGTAGTGCAACAA

Structures

Antitoxin