Detailed information of TA system TA235148

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2947671..2948004
• Replicon: chromosome
• Accession: NZ_CP091899
• Organism: Enterococcus faecalis strain 101-1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q82Z30
• Locus tag: L5I21_RS14405
• Protein ID: WP_002387585.1
• Coordinates: 2947671..2947814 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2947746..2948004 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5I21_RS14395	2943023..2943127	+	105	WP_021164545.1	putative holin-like toxin	-
L5I21_RS14400	2943317..2947075	-	3759	WP_010706868.1	WxL domain-containing protein	-
L5I21_RS14405	2947671..2947814	+	144	WP_002387585.1	putative holin-like toxin	Toxin
-	2947746..2948004	-	259	-	-	Antitoxin
L5I21_RS14410	2948004..2951063	-	3060	WP_002387586.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5244.37 Da
• Isoelectric Point: 10.5719

>T235148 WP_002387585.1 NZ_CP091899:2947671-2947814 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILKVVKEDKKK

Nucleotide

• Length: 144 bp

>T235148 NZ_LR134222:287871-288398 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATAAAAAAGCCCATACGTTTTATCAATCGCTGGGCTTTATCCCGTTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATCGAACTGCTTTTCACACAGAGCGATTAA

Antitoxin

Nucleotide

• Length: 259 bp

>AT235148 NZ_CP091899:c2948004-2947746 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTTAGAAAAATAAGAGGCTCGGGCATTTTTATTGATGGTCTTTTGATGGTCGTTGTGCTATA
ATAGCATTGAAAAGAGAGATATGCTGTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCGATTTTGTTACAA
AAAATAACCGTACTCAGTCAAAGTAAACGGTTATTTTTTCTTGTCTTCTTTAACAACCTTTAGGATTCCGAAGATTAAAG
TCGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: A0A059MXV6

Antitoxin