Detailed information of TA system TA235128

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2770550..2770807
• Replicon: chromosome
• Accession: NZ_CP091899
• Organism: Enterococcus faecalis strain 101-1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: L5I21_RS13580
• Protein ID: WP_021164441.1
• Coordinates: 2770706..2770807 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2770550..2770757 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5I21_RS13555	2766234..2767187	-	954	WP_002370087.1	siderophore ABC transporter substrate-binding protein	-
L5I21_RS13560	2767226..2767981	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
L5I21_RS13565	2767978..2768943	-	966	WP_002387376.1	iron chelate uptake ABC transporter family permease subunit	-
L5I21_RS13570	2768940..2769887	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
L5I21_RS13575	2770072..2770524	+	453	WP_002378959.1	YueI family protein	-
-	2770550..2770757	+	208	-	-	Antitoxin
L5I21_RS13580	2770706..2770807	-	102	WP_021164441.1	putative holin-like toxin	Toxin
L5I21_RS13585	2771140..2771241	-	102	WP_021164442.1	putative holin-like toxin	-
L5I21_RS13590	2771432..2773702	-	2271	WP_002399785.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
L5I21_RS13595	2773873..2774373	+	501	WP_002378961.1	cysteine hydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3598.36 Da
• Isoelectric Point: 6.0656

>T235128 WP_021164441.1 NZ_CP091899:c2770807-2770706 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNNKK

Nucleotide

• Length: 102 bp

>T235128 NZ_LR134216:c3949558-3949271 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin

Nucleotide

• Length: 208 bp

>AT235128 NZ_CP091899:2770550-2770757 [Enterococcus faecalis]
TTCCATTTTAAATAGAATTATGCTATTATGAAAATGAAAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAAC
ACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTGAATCTTAACCGTTCGGCCTACGAAGCTTGTGAACGGTTAT
TTTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin