Detailed information of TA system TA235125

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 591305..591537
• Replicon: chromosome
• Accession: NZ_CP091899
• Organism: Enterococcus faecalis strain 101-1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q837V5
• Locus tag: L5I21_RS02965
• Protein ID: WP_002366178.1
• Coordinates: 591305..591421 (+)
• Length: 39 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	591332..591537 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5I21_RS02955	586743..589001	+	2259	WP_002363179.1	DNA helicase PcrA	-
L5I21_RS02960	589127..591157	+	2031	WP_002361258.1	NAD-dependent DNA ligase LigA	-
L5I21_RS02965	591305..591421	+	117	WP_002366178.1	putative holin-like toxin	Toxin
-	591332..591537	-	206	-	-	Antitoxin
L5I21_RS02970	591739..592044	+	306	WP_002355569.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
L5I21_RS02975	592044..593513	+	1470	WP_002361259.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA	-
L5I21_RS02980	593513..594943	+	1431	WP_002358703.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB	-
L5I21_RS02985	594962..596050	+	1089	WP_002355572.1	diacylglycerol kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (3-35)

Sequences

Toxin

Protein

• Length: 39 a.a.
• Molecular weight: 4108.01 Da
• Isoelectric Point: 5.9482

>T235125 WP_002366178.1 NZ_CP091899:591305-591421 [Enterococcus faecalis]
MFLSVEAALGLMIGFATLVVTIIFVILALVLDNKNNRS

Nucleotide

• Length: 117 bp

>T235125 NZ_LR134216:3400663-3400881 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Nucleotide

• Length: 206 bp

>AT235125 NZ_CP091899:c591537-591332 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAGTAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAA
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Structures

Toxin

• AlphaFold DB: A0A1G1S9M0

Antitoxin