Detailed information of TA system TA235119

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2794527..2794864
• Replicon: chromosome
• Accession: NZ_CP091897
• Organism: Enterococcus faecalis strain 119-1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A1J6YG70
• Locus tag: L5I23_RS13390
• Protein ID: WP_002396786.1
• Coordinates: 2794527..2794670 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2794602..2794864 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5I23_RS13370	2789743..2789958	-	216	WP_002354768.1	zinc ribbon domain-containing protein	-
L5I23_RS13375	2790097..2791089	+	993	WP_002378862.1	biotin--[acetyl-CoA-carboxylase] ligase	-
L5I23_RS13380	2791256..2791894	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
L5I23_RS13385	2792579..2794195	+	1617	WP_002378864.1	phosphatase PAP2/LCP family protein	-
L5I23_RS13390	2794527..2794670	+	144	WP_002396786.1	putative holin-like toxin	Toxin
-	2794602..2794864	-	263	-	-	Antitoxin
L5I23_RS13395	2794865..2799556	-	4692	WP_002378865.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5203.19 Da
• Isoelectric Point: 8.6626

>T235119 WP_002396786.1 NZ_CP091897:2794527-2794670 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Nucleotide

• Length: 144 bp

>T235119 NZ_LR134216:1985508-1985611 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Nucleotide

• Length: 263 bp

>AT235119 NZ_CP091897:c2794864-2794602 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: A0A1J6YG70

Antitoxin