Detailed information of TA system TA235117

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2650120..2650344
• Replicon: chromosome
• Accession: NZ_CP091897
• Organism: Enterococcus faecalis strain 119-1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: L5I23_RS12720
• Protein ID: WP_224561205.1
• Coordinates: 2650243..2650344 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2650120..2650298 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5I23_RS12695	2645767..2646720	-	954	WP_002359060.1	siderophore ABC transporter substrate-binding protein	-
L5I23_RS12700	2646759..2647514	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
L5I23_RS12705	2647511..2648476	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
L5I23_RS12710	2648473..2649420	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
L5I23_RS12715	2649605..2650057	+	453	WP_002378807.1	YueI family protein	-
-	2650120..2650298	+	179	-	-	Antitoxin
L5I23_RS12720	2650243..2650344	-	102	WP_224561205.1	putative holin-like toxin	Toxin
L5I23_RS12725	2650535..2652805	-	2271	WP_002378809.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
L5I23_RS12730	2652976..2653482	+	507	WP_002378810.1	cysteine hydrolase family protein	-
L5I23_RS12735	2653672..2654568	+	897	WP_002365354.1	YitT family protein	-
L5I23_RS12740	2654619..2655017	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3629.37 Da
• Isoelectric Point: 4.5869

>T235117 WP_224561205.1 NZ_CP091897:c2650344-2650243 [Enterococcus faecalis]
MSIEATLELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

>T235117 NZ_LR134216:853249-853656 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT235117 NZ_CP091897:2650120-2650298 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTT
TTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCG
AAAATCAGTAGTGCAACAA

Structures

Antitoxin