Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 614561..614793 Replicon chromosome
Accession NZ_CP091897
Organism Enterococcus faecalis strain 119-1

Toxin (Protein)


Gene name txpA Uniprot ID C7CXQ5
Locus tag L5I23_RS03010 Protein ID WP_002355568.1
Coordinates 614561..614677 (+) Length 39 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 614588..614793 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5I23_RS03000 609999..612257 + 2259 WP_002363179.1 DNA helicase PcrA -
L5I23_RS03005 612383..614413 + 2031 WP_002378031.1 NAD-dependent DNA ligase LigA -
L5I23_RS03010 614561..614677 + 117 WP_002355568.1 putative holin-like toxin Toxin
- 614588..614793 - 206 - - Antitoxin
L5I23_RS03015 614995..615300 + 306 WP_002355569.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
L5I23_RS03020 615300..616769 + 1470 WP_002358701.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
L5I23_RS03025 616769..618199 + 1431 WP_002358703.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
L5I23_RS03030 618218..619306 + 1089 WP_002355572.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(3-35)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4065.93 Da        Isoelectric Point: 5.9482

>T235109 WP_002355568.1 NZ_CP091897:614561-614677 [Enterococcus faecalis]
MFLSVEAALGLMIGFATLVVTIIFGILALVLDNKNNRS

Download         Length: 117 bp

>T235109 NZ_LR134215:2145173-2145355 [Shimwellia blattae]
CTGAAGAGCTCGGAACTGATATCACTACTGGAGAAAAATGGCTGGGTCCTGGAGCGCATCAAAGGCAGCCATCACCAGTT
CTCCCATCCCGATTTTGCTATTGTCATTACTGTTCCGCATCCCAGAAAAGACGTGAAGCCAGGAACGCTCCGTCAGATCC
TGAAGAATGCGAAGCTAAAATGA

Antitoxin


Download         Length: 206 bp

>AT235109 NZ_CP091897:c614793-614588 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4XLM6

Antitoxin

Download structure file

References