Detailed information of TA system TA235100

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2639416..2639640
• Replicon: chromosome
• Accession: NZ_CP091895
• Organism: Enterococcus faecalis strain 119-2

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: L5I25_RS12640
• Protein ID: WP_224561205.1
• Coordinates: 2639539..2639640 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2639416..2639594 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5I25_RS12615	2635063..2636016	-	954	WP_002359060.1	siderophore ABC transporter substrate-binding protein	-
L5I25_RS12620	2636055..2636810	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
L5I25_RS12625	2636807..2637772	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
L5I25_RS12630	2637769..2638716	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
L5I25_RS12635	2638901..2639353	+	453	WP_002378807.1	YueI family protein	-
-	2639416..2639594	+	179	-	-	Antitoxin
L5I25_RS12640	2639539..2639640	-	102	WP_224561205.1	putative holin-like toxin	Toxin
L5I25_RS12645	2639831..2642101	-	2271	WP_002378809.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
L5I25_RS12650	2642272..2642778	+	507	WP_002378810.1	cysteine hydrolase family protein	-
L5I25_RS12655	2642968..2643864	+	897	WP_002365354.1	YitT family protein	-
L5I25_RS12660	2643915..2644313	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3629.37 Da
• Isoelectric Point: 4.5869

>T235100 WP_224561205.1 NZ_CP091895:c2639640-2639539 [Enterococcus faecalis]
MSIEATLELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

>T235100 NZ_LR134215:c56365-56144 [Shimwellia blattae]
GTGCATTACTGTATTCATACGACGCTCGCTCGTAAGCTCGACATCATCAATGCTGCCGTGACATATCTGGATTTAAGATC
GCCTCCAGGCAACAGATATGAAGAGCTAAACGGCAAACTGGAAGGTTATTCGTCAATTCGTATTAACCAGCAGTATCGCC
TGATATTTAAGTGGGTGAACGGAAAAGCAGAAGACCTCTACCTGGATCCGCATAAATACTGA

Antitoxin

Nucleotide

• Length: 179 bp

>AT235100 NZ_CP091895:2639416-2639594 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTT
TTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCG
AAAATCAGTAGTGCAACAA

Structures

Antitoxin