Detailed information of TA system TA235085

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2838174..2838510
• Replicon: chromosome
• Accession: NZ_CP091892
• Organism: Enterococcus faecalis strain 133-1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A1J6YG70
• Locus tag: L5I22_RS13640
• Protein ID: WP_002396786.1
• Coordinates: 2838174..2838317 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2838461..2838510 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5I22_RS13620 (2833291)	2833291..2833506	-	216	WP_002354768.1	zinc ribbon domain-containing protein	-
L5I22_RS13625 (2833645)	2833645..2834637	+	993	WP_023894581.1	biotin--[acetyl-CoA-carboxylase] ligase	-
L5I22_RS13630 (2834901)	2834901..2835539	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
L5I22_RS13635 (2836225)	2836225..2837841	+	1617	WP_047648929.1	phosphatase PAP2/LCP family protein	-
L5I22_RS13640 (2838174)	2838174..2838317	+	144	WP_002396786.1	putative holin-like toxin	Toxin
- (2838461)	2838461..2838510	+	50	NuclAT_16	-	Antitoxin
- (2838249)	2838249..2838511	-	263	NuclAT_12	-	-
L5I22_RS13645 (2838512)	2838512..2843203	-	4692	WP_049098584.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5203.19 Da
• Isoelectric Point: 8.6626

>T235085 WP_002396786.1 NZ_CP091892:2838174-2838317 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Nucleotide

• Length: 144 bp

>T235085 NZ_LR134211:c142258-141788 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
TTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin

Nucleotide

• Length: 50 bp

>AT235085 NZ_CP091892:2838461-2838510 [Enterococcus faecalis]
AATAAAAATGCCCGAGCCTTAGAAAAATAAGAGGCTCGGGCATTTTTATT

Structures

Toxin

• AlphaFold DB: A0A1J6YG70

Antitoxin