Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | txpA-ratA/- |
| Location | 2713515..2713789 | Replicon | chromosome |
| Accession | NZ_CP091892 | ||
| Organism | Enterococcus faecalis strain 133-1 | ||
Toxin (Protein)
| Gene name | txpA | Uniprot ID | S4BYM2 |
| Locus tag | L5I22_RS13110 | Protein ID | WP_002392696.1 |
| Coordinates | 2713646..2713789 (-) | Length | 48 a.a. |
Antitoxin (RNA)
| Gene name | ratA | ||
| Locus tag | - | ||
| Coordinates | 2713515..2713713 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L5I22_RS13090 (2709117) | 2709117..2711861 | + | 2745 | WP_047648974.1 | glycosyl hydrolase family 65 protein | - |
| L5I22_RS13095 (2711876) | 2711876..2712526 | + | 651 | WP_002354875.1 | beta-phosphoglucomutase | - |
| - (2712581) | 2712581..2712721 | + | 141 | NuclAT_11 | - | - |
| - (2712777) | 2712777..2712922 | + | 146 | NuclAT_13 | - | - |
| - (2712777) | 2712777..2712963 | + | 187 | NuclAT_10 | - | - |
| L5I22_RS13100 (2712896) | 2712896..2713000 | - | 105 | WP_023894767.1 | putative holin-like toxin | - |
| - (2713152) | 2713152..2713297 | + | 146 | NuclAT_14 | - | - |
| - (2713140) | 2713140..2713338 | + | 199 | NuclAT_9 | - | - |
| L5I22_RS13105 (2713271) | 2713271..2713375 | - | 105 | WP_023894767.1 | putative holin-like toxin | - |
| - (2713527) | 2713527..2713672 | + | 146 | NuclAT_15 | - | - |
| - (2713515) | 2713515..2713713 | + | 199 | NuclAT_8 | - | Antitoxin |
| L5I22_RS13110 (2713646) | 2713646..2713789 | - | 144 | WP_002392696.1 | type I toxin-antitoxin system toxin PepG1 | Toxin |
| L5I22_RS13115 (2714021) | 2714021..2714992 | - | 972 | WP_002381060.1 | ribose-phosphate diphosphokinase | - |
| L5I22_RS13120 (2715167) | 2715167..2715604 | - | 438 | WP_002354871.1 | peptide-methionine (R)-S-oxide reductase MsrB | - |
| L5I22_RS13125 (2715737) | 2715737..2716291 | - | 555 | WP_002354869.1 | Maf family protein | - |
| L5I22_RS13130 (2716316) | 2716316..2718448 | - | 2133 | WP_002378991.1 | DNA mismatch repair endonuclease MutL | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 48 a.a. Molecular weight: 5297.43 Da Isoelectric Point: 10.6867
>T235078 WP_002392696.1 NZ_CP091892:c2713789-2713646 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK
Download Length: 144 bp
>T235078 NZ_LR134209:3538599-3538817 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
Antitoxin
Download Length: 199 bp
>AT235078 NZ_CP091892:2713515-2713713 [Enterococcus faecalis]
TTTTTAGGGAAATGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGA
CGGTGACCGATTGTATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAAGCAATT
TCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA
TTTTTAGGGAAATGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGA
CGGTGACCGATTGTATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAAGCAATT
TCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
