Detailed information of TA system TA235069

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2712896..2713338
• Replicon: chromosome
• Accession: NZ_CP091892
• Organism: Enterococcus faecalis strain 133-1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: L5I22_RS13100
• Protein ID: WP_023894767.1
• Coordinates: 2712896..2713000 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2713140..2713338 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5I22_RS13085 (2708142)	2708142..2708855	-	714	WP_002367455.1	trehalose operon repressor	-
L5I22_RS13090 (2709117)	2709117..2711861	+	2745	WP_047648974.1	glycosyl hydrolase family 65 protein	-
L5I22_RS13095 (2711876)	2711876..2712526	+	651	WP_002354875.1	beta-phosphoglucomutase	-
- (2712581)	2712581..2712721	+	141	NuclAT_11	-	-
- (2712777)	2712777..2712922	+	146	NuclAT_13	-	-
- (2712777)	2712777..2712963	+	187	NuclAT_10	-	-
L5I22_RS13100 (2712896)	2712896..2713000	-	105	WP_023894767.1	putative holin-like toxin	Toxin
- (2713152)	2713152..2713297	+	146	NuclAT_14	-	-
- (2713140)	2713140..2713338	+	199	NuclAT_9	-	Antitoxin
L5I22_RS13105 (2713271)	2713271..2713375	-	105	WP_023894767.1	putative holin-like toxin	-
- (2713527)	2713527..2713672	+	146	NuclAT_15	-	-
- (2713515)	2713515..2713713	+	199	NuclAT_8	-	-
L5I22_RS13110 (2713646)	2713646..2713789	-	144	WP_002392696.1	type I toxin-antitoxin system toxin PepG1	-
L5I22_RS13115 (2714021)	2714021..2714992	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
L5I22_RS13120 (2715167)	2715167..2715604	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
L5I22_RS13125 (2715737)	2715737..2716291	-	555	WP_002354869.1	Maf family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-34)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3799.63 Da
• Isoelectric Point: 10.0079

>T235069 WP_023894767.1 NZ_CP091892:c2713000-2712896 [Enterococcus faecalis]
MSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 105 bp

>T235069 NZ_LR134209:870719-871126 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Nucleotide

• Length: 199 bp

>AT235069 NZ_CP091892:2713140-2713338 [Enterococcus faecalis]
TTTTTAGGGAAATGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGA
CGGTGACCGATTTTGTTACAAAAAATAACCGTACTCGATCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAAGCAATT
TCACAATCAGCGCAATCAAAGCAATGGTAAACATACCAA

Structures

Antitoxin