Detailed information of TA system TA235063

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2641044..2641269
• Replicon: chromosome
• Accession: NZ_CP091892
• Organism: Enterococcus faecalis strain 133-1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: L5I22_RS12760
• Protein ID: WP_075551663.1
• Coordinates: 2641168..2641269 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2641044..2641223 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5I22_RS12730 (2636260)	2636260..2637213	-	954	WP_002394760.1	siderophore ABC transporter substrate-binding protein	-
L5I22_RS12735 (2637252)	2637252..2638007	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
L5I22_RS12740 (2638004)	2638004..2638969	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
L5I22_RS12745 (2638966)	2638966..2639913	-	948	WP_002359058.1	iron chelate uptake ABC transporter family permease subunit	-
L5I22_RS12750 (2640098)	2640098..2640550	+	453	WP_002359057.1	YueI family protein	-
- (2640576)	2640576..2640786	+	211	NuclAT_6	-	-
- (2640613)	2640613..2640790	+	178	NuclAT_5	-	-
L5I22_RS12755 (2640735)	2640735..2640836	-	102	WP_075551663.1	putative holin-like toxin	-
- (2641010)	2641010..2641219	+	210	NuclAT_7	-	-
- (2641044)	2641044..2641223	+	180	NuclAT_4	-	Antitoxin
L5I22_RS12760 (2641168)	2641168..2641269	-	102	WP_075551663.1	putative holin-like toxin	Toxin
L5I22_RS12765 (2641459)	2641459..2643729	-	2271	WP_002354955.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
L5I22_RS12770 (2643900)	2643900..2644400	+	501	WP_010709949.1	cysteine hydrolase family protein	-
L5I22_RS12775 (2644703)	2644703..2645599	+	897	WP_002354953.1	YitT family protein	-
L5I22_RS12780 (2645650)	2645650..2646048	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3599.34 Da
• Isoelectric Point: 4.5869

>T235063 WP_075551663.1 NZ_CP091892:c2641269-2641168 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

>T235063 NZ_LR134205:3064598-3065167 [Proteus mirabilis]
ATGACAAACTATACTGTTTTGCTTGATGCCTGTGTCATGTATCCAGCCCCTCTTAGAAGTTATTTAATGTATCTTGCTAA
TACTGGTTTATTTAGAGCACGTTGGAGTAATCAGATCCATGATGAATGGATCACTAATTTATTAGTCAACAATCCAACAT
TAACAGCTGAGCGACTAATACGAACCAGAGATTTAATGAATGCACATGTTCCTGATTGTTTAGTAGAAGGCTACGAACCG
CTTATTTGTGGTTTAAAGCTACCTGATCCTAATGATCGTCATGTGCTAGCAGCAGCAATAAAAGGGCAGGCTCAAGCTAT
AATTACATTTAACTTAAAAGATTTTCCGCAAAAATACCTTAATTCTTTTGATATTTCAGCTATCCATCCTGATGAATTTT
TGAGTGACATGTTTGAATTAAATCCTAGTAGCTGTATTAAAGCGGCGCAACAACATAGACAAAGCCTAAAGGATCCACCA
ATGACCGTAGAGACCTTTTTAGGCTGTTTACAAAAGCAGAAATTACCCCAGTTTATTTCCCATTTACGGGCATTCCAGAT
ATTATTATAA

Antitoxin

Nucleotide

• Length: 180 bp

>AT235063 NZ_CP091892:2641044-2641223 [Enterococcus faecalis]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGT
TTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACC
GAAAATCAGTAGTGCAACAA

Structures

Antitoxin