Detailed information of TA system TA235045

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): fst-RNAII/Fst(toxin)
• Location: 74982..75196
• Replicon: plasmid p1
• Accession: NZ_CP091890
• Organism: Enterococcus faecalis strain 142-1

Toxin (Protein)

• Gene name: fst
• Uniprot ID: -
• Locus tag: L5I18_RS16335
• Protein ID: WP_002360667.1
• Coordinates: 74982..75092 (+)
• Length: 37 a.a.

Antitoxin (RNA)

Gene name	RNAII
Locus tag	-
Coordinates	75132..75196 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5I18_RS16285	70107..70469	-	363	WP_000241511.1	type II toxin-antitoxin system PemK/MazF family toxin	-
L5I18_RS16290	70463..70726	-	264	WP_000245205.1	PbsX family transcriptional regulator	-
L5I18_RS16295	70903..71523	+	621	WP_021732893.1	recombinase family protein	-
L5I18_RS16300	71540..71827	+	288	WP_010708491.1	hypothetical protein	-
L5I18_RS16305	71821..72045	+	225	WP_010708492.1	ultraviolet resistance protein UvrA repressor UvrC	-
L5I18_RS16310	72106..72315	+	210	WP_002387638.1	hypothetical protein	-
L5I18_RS16315	72477..72629	+	153	WP_225850000.1	DUF6440 family protein	-
L5I18_RS16320	73056..74384	+	1329	WP_021732894.1	ultraviolet resistance protein UvrA	-
L5I18_RS16325	74381..74731	+	351	WP_002399364.1	hypothetical protein	-
L5I18_RS16330	74688..74900	+	213	WP_002360669.1	hypothetical protein	-
L5I18_RS16335	74982..75092	+	111	WP_002360667.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	75132..75196	-	65	-	-	Antitoxin
L5I18_RS16340	75332..75628	+	297	WP_002360665.1	replication control protein PrgN	-
L5I18_RS16345	75882..76664	+	783	WP_002360664.1	ParA family protein	-
L5I18_RS16350	76657..77013	+	357	WP_002360663.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	-	prgB/asc10	1..77272	77272

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 37 a.a.
• Molecular weight: 4117.92 Da
• Isoelectric Point: 4.1672

>T235045 WP_002360667.1 NZ_CP091890:74982-75092 [Enterococcus faecalis]
VLFVKDLMSLVIAPIFVGLVLEMISRVLDEEDDNRK

Nucleotide

• Length: 111 bp

>T235045 NZ_LR134196:315554-315922 [Klebsiella quasipneumoniae]
ATGACGCTGCAAATTATCTCAGCGGAAGAGATAATACAGTTTCATGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGACCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAATCAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCACCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCTGC
AGCGGGGCAACTTACTCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin

Nucleotide

• Length: 65 bp

>AT235045 NZ_CP091890:c75196-75132 [Enterococcus faecalis]
AACGACATTAAATCGTACAAATAACACAAAAAGCAATCCTACGGCGAATAGGATTGCTTTTTTTT

Structures

Antitoxin