Detailed information of TA system TA235041

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-RNAII/-
• Location: 3064880..3065217
• Replicon: chromosome
• Accession: NZ_CP091889
• Organism: Enterococcus faecalis strain 142-1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A1J6YG70
• Locus tag: L5I18_RS15390
• Protein ID: WP_002396786.1
• Coordinates: 3064880..3065023 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	RNAII
Locus tag	-
Coordinates	3064955..3065217 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5I18_RS15370 (3059997)	3059997..3060212	-	216	WP_002354768.1	zinc ribbon domain-containing protein	-
L5I18_RS15375 (3060351)	3060351..3061343	+	993	WP_023894581.1	biotin--[acetyl-CoA-carboxylase] ligase	-
L5I18_RS15380 (3061607)	3061607..3062245	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
L5I18_RS15385 (3062931)	3062931..3064547	+	1617	WP_047648929.1	phosphatase PAP2/LCP family protein	-
L5I18_RS15390 (3064880)	3064880..3065023	+	144	WP_002396786.1	putative holin-like toxin	Toxin
- (3065167)	3065167..3065216	+	50	NuclAT_12	-	-
- (3064955)	3064955..3065217	-	263	NuclAT_10	-	Antitoxin
L5I18_RS15395 (3065218)	3065218..3069909	-	4692	WP_049098584.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5203.19 Da
• Isoelectric Point: 8.6626

>T235041 WP_002396786.1 NZ_CP091889:3064880-3065023 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Nucleotide

• Length: 144 bp

>T235041 NZ_LR134195:2725347-2725829 [Raoultella ornithinolytica]
ATGGGAATGAGACCACCGGAACCACTCAGCGCTGGACACAACATAGCAGAATTTTGTTGTCAGGATCAGGTTCTTAACGA
GTGGTTGAAGAAGAAGGCGCTGAAGAACCACAGTACAGGCATTTCAAGGGTCTTTGTGGTCTGTGCCGAAAACACAAAAA
GGGTCATCGCGTATTACAGCTTGTCATCCGGGAGCGTGCACAGAAACACAGTAACGGGGGCATACCGTCGTAATGCACCT
GAAGCTGTACCGGTCATTGTTCTGGGAAGGCTTGCGGTCGATGCAGCCTGGGCAGGGAAGGGACTCGGAGCGGCACTGCT
TAAGGATGCAATATACCGTACAGAACATATCGCAGTTCAGGTCGGTGTAAGGGCGCTTCTCGTCCATGCCTTGAATGATG
AAGTCAGGGAGTTTTACACCAGGTTTGGATTCGAGCCCTCGATTATCAATACACTGACATTATTGTTCCCGATAAAAGTA
TGA

Antitoxin

Nucleotide

• Length: 263 bp

>AT235041 NZ_CP091889:c3065217-3064955 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: A0A1J6YG70

Antitoxin