Detailed information of TA system TA235037

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2986807..2987069
• Replicon: chromosome
• Accession: NZ_CP091889
• Organism: Enterococcus faecalis strain 142-1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: S4BYM2
• Locus tag: L5I18_RS15050
• Protein ID: WP_002392696.1
• Coordinates: 2986926..2987069 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2986807..2986993 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5I18_RS15035 (2982172)	2982172..2982885	-	714	WP_002367455.1	trehalose operon repressor	-
L5I18_RS15040 (2983147)	2983147..2985891	+	2745	WP_047648974.1	glycosyl hydrolase family 65 protein	-
L5I18_RS15045 (2985906)	2985906..2986556	+	651	WP_002354875.1	beta-phosphoglucomutase	-
- (2986611)	2986611..2986751	+	141	NuclAT_9	-	-
- (2986807)	2986807..2986952	+	146	NuclAT_11	-	-
- (2986807)	2986807..2986993	+	187	NuclAT_8	-	Antitoxin
L5I18_RS15050 (2986926)	2986926..2987069	-	144	WP_002392696.1	type I toxin-antitoxin system toxin PepG1	Toxin
L5I18_RS15055 (2987301)	2987301..2988272	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
L5I18_RS15060 (2988447)	2988447..2988884	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
L5I18_RS15065 (2989017)	2989017..2989571	-	555	WP_002354869.1	Maf family protein	-
L5I18_RS15070 (2989596)	2989596..2991728	-	2133	WP_002378991.1	DNA mismatch repair endonuclease MutL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5297.43 Da
• Isoelectric Point: 10.6867

>T235037 WP_002392696.1 NZ_CP091889:c2987069-2986926 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 144 bp

>T235037 NZ_LR134195:c67409-67101 [Raoultella ornithinolytica]
ATACAGTATTACGTTTATAAAAATACCGGTCGAATTACTGTGTATCCTTATCTCCTTGATGTACAAAGTGACATTATTGG
AATGCGCAATACCCGGGTCGTGATCCCACTATTCCCGCTGAGAAATTACAAAGGTCCGCGCGCCGATCGTTTAACACCAG
TTGTCACCGTAGAAGGGGAAGAATACGTCGTGATGACTCACGAACTCGCCAGCATCCCACAACGCGTTCTGGGGGAAGAG
GTTTGTCATCTCAATCACCAACGTGAAGTCGTTAAAGCATCAATAGATTTTCTTTTTGACGGGATTTAA

Antitoxin

Nucleotide

• Length: 187 bp

>AT235037 NZ_CP091889:2986807-2986993 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCGATT
GTATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGTG
CAATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: S4BYM2

Antitoxin