Detailed information of TA system TA235034

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2916678..2916903
• Replicon: chromosome
• Accession: NZ_CP091889
• Organism: Enterococcus faecalis strain 142-1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: L5I18_RS14725
• Protein ID: WP_075551663.1
• Coordinates: 2916802..2916903 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2916678..2916857 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5I18_RS14695 (2911894)	2911894..2912847	-	954	WP_002394760.1	siderophore ABC transporter substrate-binding protein	-
L5I18_RS14700 (2912886)	2912886..2913641	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
L5I18_RS14705 (2913638)	2913638..2914603	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
L5I18_RS14710 (2914600)	2914600..2915547	-	948	WP_002359058.1	iron chelate uptake ABC transporter family permease subunit	-
L5I18_RS14715 (2915732)	2915732..2916184	+	453	WP_002359057.1	YueI family protein	-
- (2916210)	2916210..2916420	+	211	NuclAT_6	-	-
- (2916247)	2916247..2916424	+	178	NuclAT_5	-	-
L5I18_RS14720 (2916369)	2916369..2916470	-	102	WP_075551663.1	putative holin-like toxin	-
- (2916644)	2916644..2916853	+	210	NuclAT_7	-	-
- (2916678)	2916678..2916857	+	180	NuclAT_4	-	Antitoxin
L5I18_RS14725 (2916802)	2916802..2916903	-	102	WP_075551663.1	putative holin-like toxin	Toxin
L5I18_RS14730 (2917093)	2917093..2919363	-	2271	WP_002354955.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
L5I18_RS14735 (2919534)	2919534..2920034	+	501	WP_010709949.1	cysteine hydrolase family protein	-
L5I18_RS14740 (2920337)	2920337..2921233	+	897	WP_238463976.1	YitT family protein	-
L5I18_RS14745 (2921284)	2921284..2921682	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3599.34 Da
• Isoelectric Point: 4.5869

>T235034 WP_075551663.1 NZ_CP091889:c2916903-2916802 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

>T235034 NZ_LR134193:c2487927-2487661 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAAGCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin

Nucleotide

• Length: 180 bp

>AT235034 NZ_CP091889:2916678-2916857 [Enterococcus faecalis]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGT
TTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACC
GAAAATCAGTAGTGCAACAA

Structures

Antitoxin