Detailed information of TA system TA235016

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2831921..2832257
• Replicon: chromosome
• Accession: NZ_CP091886
• Organism: Enterococcus faecalis strain 143-1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A1J6YG70
• Locus tag: L5I19_RS13810
• Protein ID: WP_002396786.1
• Coordinates: 2831921..2832064 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2832208..2832257 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5I19_RS13790	2827137..2827352	-	216	WP_002354768.1	zinc ribbon domain-containing protein	-
L5I19_RS13795	2827491..2828483	+	993	WP_002378862.1	biotin--[acetyl-CoA-carboxylase] ligase	-
L5I19_RS13800	2828650..2829288	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
L5I19_RS13805	2829973..2831589	+	1617	WP_002378864.1	phosphatase PAP2/LCP family protein	-
L5I19_RS13810	2831921..2832064	+	144	WP_002396786.1	putative holin-like toxin	Toxin
-	2832208..2832257	+	50	-	-	Antitoxin
L5I19_RS13815	2832259..2836950	-	4692	WP_002378865.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5203.19 Da
• Isoelectric Point: 8.6626

>T235016 WP_002396786.1 NZ_CP091886:2831921-2832064 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Nucleotide

• Length: 144 bp

>T235016 NZ_LR134189:615974-616294 [Providencia rustigianii]
ATGGAGGAGGTTTATGTGAATGAAGATAATGATTGTCGTTTAATTTTTAGAGATGAGTATTTACGACTATTTTATGTCTA
TGGCAAGTTACATCGTCTAATTCCGTCTATCATCTGCACTGTTTTAGCCCGAAAGTTAGACATGCTAAATGCAGCGAAAA
CATTACAGGATTTTAAAAGTCCCCCAGGAAATCGGTTTAAGCAGCTGAAACCACCGTTGGAAGAATTTTACTCAATTAGA
GTTAATGGGCAGTATCGGCTTATATTTAAATGGAAAGATACAGTCGAGGGATTGTATTTGGATCCTCATAAAGATGTTTA
G

Antitoxin

Nucleotide

• Length: 50 bp

>AT235016 NZ_CP091886:2832208-2832257 [Enterococcus faecalis]
AATAAAAATGCCCGAGCCTTAGAAAAATAAGAGGCTCGGGCATTTTTATT

Structures

Toxin

• AlphaFold DB: A0A1J6YG70

Antitoxin