Detailed information of TA system TA235008

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2687477..2687738
• Replicon: chromosome
• Accession: NZ_CP091886
• Organism: Enterococcus faecalis strain 143-1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: L5I19_RS13140
• Protein ID: WP_224561205.1
• Coordinates: 2687637..2687738 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2687477..2687688 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5I19_RS13115	2683161..2684114	-	954	WP_002359060.1	siderophore ABC transporter substrate-binding protein	-
L5I19_RS13120	2684153..2684908	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
L5I19_RS13125	2684905..2685870	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
L5I19_RS13130	2685867..2686814	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
L5I19_RS13135	2686999..2687451	+	453	WP_002378807.1	YueI family protein	-
-	2687477..2687688	+	212	-	-	Antitoxin
L5I19_RS13140	2687637..2687738	-	102	WP_224561205.1	putative holin-like toxin	Toxin
L5I19_RS13145	2687929..2690199	-	2271	WP_002378809.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
L5I19_RS13150	2690370..2690876	+	507	WP_002378810.1	cysteine hydrolase family protein	-
L5I19_RS13155	2691066..2691962	+	897	WP_002365354.1	YitT family protein	-
L5I19_RS13160	2692013..2692411	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3629.37 Da
• Isoelectric Point: 4.5869

>T235008 WP_224561205.1 NZ_CP091886:c2687738-2687637 [Enterococcus faecalis]
MSIEATLELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

>T235008 NZ_LR134171:969175-969438 [Haemophilus influenzae]
ATGATTTCAGTGAGTGGGGAATATAAAAGAGAATTTAAAAAACATATTCCTCTTATTATAAATAGTCCAGAATATATTGA
AGTTATGTATTGTCTTTTGAATAGCTTACCATTACCAGAAAAATATAAAGATCATGCTTTAACTGGAAATTGGAAAGGTT
GGAGAGATTGCCATATAAAGAATGATCTTGTGCTTATTTATAAAGTGGTGGGAGATGAAATAAGGCTAGCTCGTCTTAAT
ACTCATTCAGAAATTTTTGGTTAA

Antitoxin

Nucleotide

• Length: 212 bp

>AT235008 NZ_CP091886:2687477-2687688 [Enterococcus faecalis]
TTCCATTTATAATAGAATTATGCTATTATGAAAATGAAAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAAC
ACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGG
TTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin