Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2853299..2853635 Replicon chromosome
Accession NZ_CP091884
Organism Enterococcus faecalis strain 152

Toxin (Protein)


Gene name txpA Uniprot ID A0A1J6YG70
Locus tag L5I24_RS13955 Protein ID WP_002396786.1
Coordinates 2853299..2853442 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2853586..2853635 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5I24_RS13935 2848515..2848730 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
L5I24_RS13940 2848869..2849861 + 993 WP_002378862.1 biotin--[acetyl-CoA-carboxylase] ligase -
L5I24_RS13945 2850028..2850666 - 639 WP_002378863.1 lytic polysaccharide monooxygenase -
L5I24_RS13950 2851351..2852967 + 1617 WP_002378864.1 phosphatase PAP2/LCP family protein -
L5I24_RS13955 2853299..2853442 + 144 WP_002396786.1 putative holin-like toxin Toxin
- 2853586..2853635 + 50 - - Antitoxin
L5I24_RS13960 2853637..2858328 - 4692 WP_002378865.1 WxL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5203.19 Da        Isoelectric Point: 8.6626

>T234995 WP_002396786.1 NZ_CP091884:2853299-2853442 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Download         Length: 144 bp

>T234995 NZ_LR134168:77042-77332 [Haemophilus influenzae]
ATGACTTATAAACTCATTTTTGATAAACGTGCATTAAAAGAATGGAATAAGTTAGGAGAAACTTTACGCCAGCAATTTAA
AAATAAATTAGCCGAAAGAATGATAAATCCACGCATTCAAGCCGATAAATTAAAGGGCGAAAATGATTTATATAAAATAA
AATTAAGAAGCGCAGGCTATCGATTAGTTTATCAAGTAAGAGATCAGGAAATCACCATTATTGTTGTATCTATTGGAAAA
AGGGAACGATTAGAAGTCTATAAAACCGCAGAACAAAGAACAGCCCACTAA

Antitoxin


Download         Length: 50 bp

>AT234995 NZ_CP091884:2853586-2853635 [Enterococcus faecalis]
AATAAAAATGCCCGAGCCTTAGAAAAATAAGAGGCTCGGGCATTTTTATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J6YG70

Antitoxin

Download structure file

References