Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/MqsA(antitoxin)
Location 1806150..1806765 Replicon chromosome
Accession NC_011901
Organism Thioalkalivibrio sulfidophilus HL-EbGr7

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag TGR7_RS08555 Protein ID WP_012638272.1
Coordinates 1806150..1806464 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag TGR7_RS08560 Protein ID WP_095206578.1
Coordinates 1806454..1806765 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TGR7_RS08525 1801254..1801964 + 711 WP_012638266.1 protein glxC -
TGR7_RS08530 1801968..1803314 + 1347 WP_012638267.1 FMN-binding glutamate synthase family protein -
TGR7_RS08535 1803311..1803982 + 672 WP_041441337.1 XRE family transcriptional regulator -
TGR7_RS08540 1803966..1804427 + 462 WP_012638269.1 GNAT family N-acetyltransferase -
TGR7_RS17440 1804637..1805047 + 411 WP_148211481.1 hypothetical protein -
TGR7_RS08545 1805526..1805723 + 198 Protein_1705 transposase -
TGR7_RS08550 1805749..1806051 + 303 Protein_1706 transposase -
TGR7_RS08555 1806150..1806464 + 315 WP_012638272.1 transcriptional regulator Toxin
TGR7_RS08560 1806454..1806765 + 312 WP_095206578.1 helix-turn-helix domain-containing protein Antitoxin
TGR7_RS08565 1807079..1809046 + 1968 WP_148211580.1 cache domain-containing protein -
TGR7_RS08570 1809230..1810018 - 789 WP_012638275.1 methyltransferase domain-containing protein -
TGR7_RS08575 1810136..1810582 - 447 WP_012638276.1 DUF302 domain-containing protein -
TGR7_RS08580 1810924..1811574 + 651 WP_081434269.1 sigma-70 family RNA polymerase sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1805526..1824249 18723


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(46-89)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11671.43 Da        Isoelectric Point: 8.9722

>T23499 WP_012638272.1 NC_011901:1806150-1806464 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
MLTIIESPLFSKLWPDYWSVEEHGEFTTHLAGNPEAGDLIPGSGGCRKIRWTRPGMGKRGGVRVIYTVRLKRGTVVLLTI
YSKSAKDNIPSHVLRQIAEELDHD

Download         Length: 315 bp

>T23499 NC_011901:1806150-1806464 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
ATGCTGACCATCATTGAGTCGCCACTCTTTAGCAAGCTCTGGCCTGACTACTGGTCGGTTGAGGAGCACGGCGAGTTCAC
CACCCATCTGGCGGGCAACCCCGAAGCTGGCGACTTGATCCCCGGTTCCGGTGGGTGTCGCAAGATCCGGTGGACTCGCC
CCGGGATGGGCAAACGCGGCGGTGTACGAGTCATCTACACCGTGCGCCTCAAACGCGGCACAGTAGTGCTGCTCACAATC
TATTCCAAGAGCGCGAAGGACAATATTCCATCGCATGTATTGCGCCAGATCGCGGAGGAACTTGATCATGACTAG

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11187.70 Da        Isoelectric Point: 10.9032

>AT23499 WP_095206578.1 NC_011901:1806454-1806765 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
IMTSKKSISARDANRNIGEELLQAIRDVKNGKHGAKYSVEANDVVAARLKSGLSQAQFAAALHISSRTLQQWEQGRRQPS
GAAATLLKIVSRHPEVLREVADA

Download         Length: 312 bp

>AT23499 NC_011901:1806454-1806765 [Thioalkalivibrio sulfidiphilus HL-EbGr7]
ATCATGACTAGCAAAAAGTCCATTTCAGCGCGTGATGCGAACCGTAACATCGGTGAAGAGCTGCTGCAGGCCATTCGTGA
CGTCAAGAACGGAAAGCACGGCGCCAAGTACAGCGTTGAGGCCAATGACGTGGTTGCGGCGCGCCTCAAGTCGGGCCTTT
CGCAGGCGCAGTTTGCTGCCGCCCTGCATATTTCGTCCCGCACGCTTCAGCAATGGGAGCAAGGGCGCCGGCAGCCATCT
GGTGCGGCTGCAACCCTTCTTAAGATTGTGTCTCGCCATCCAGAGGTTCTTCGTGAGGTCGCAGACGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References