Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5419082..5419677 Replicon chromosome
Accession NZ_CP091880
Organism Pseudomonas aeruginosa strain US449

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag L8E65_RS25230 Protein ID WP_003113526.1
Coordinates 5419399..5419677 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag L8E65_RS25225 Protein ID WP_003133769.1
Coordinates 5419082..5419387 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L8E65_RS25190 (L8E65_25175) 5414223..5415071 + 849 WP_047690002.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
L8E65_RS25200 (L8E65_25185) 5415238..5416179 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
L8E65_RS25205 (L8E65_25190) 5416296..5416910 + 615 WP_047690000.1 50S ribosomal protein L25/general stress protein Ctc -
L8E65_RS25210 (L8E65_25195) 5416952..5417536 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
L8E65_RS25215 (L8E65_25200) 5417577..5418677 + 1101 WP_047689997.1 redox-regulated ATPase YchF -
L8E65_RS25225 (L8E65_25210) 5419082..5419387 - 306 WP_003133769.1 HigA family addiction module antitoxin Antitoxin
L8E65_RS25230 (L8E65_25215) 5419399..5419677 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L8E65_RS25235 (L8E65_25220) 5419730..5419858 - 129 Protein_4992 integrase -
L8E65_RS25240 (L8E65_25225) 5420006..5422234 + 2229 WP_003099265.1 TonB-dependent receptor -
L8E65_RS25245 (L8E65_25230) 5422304..5422951 - 648 WP_003095021.1 carbonate dehydratase -
L8E65_RS25250 (L8E65_25235) 5423013..5424251 - 1239 WP_047689994.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T234977 WP_003113526.1 NZ_CP091880:c5419677-5419399 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T234977 NZ_LR134163:4438924-4439017 [Yersinia pseudotuberculosis]
TAAGCCTACATTAATACCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATCAGGAATCGTA
TTCGGTCTTTTTTT

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11214.73 Da        Isoelectric Point: 4.6081

>AT234977 WP_003133769.1 NZ_CP091880:c5419387-5419082 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp

>AT234977 NZ_LR134163:c4439018-4438924 [Yersinia pseudotuberculosis]
TAAAAAAAGACCGAATACGATTCCTGATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGT
ATTAATGTAGGCTTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References