Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4627922..4628676 | Replicon | chromosome |
| Accession | NZ_CP091878 | ||
| Organism | Salmonella enterica subsp. enterica serovar Tennessee strain 21-SA00318-0 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | B5F003 |
| Locus tag | L8I56_RS22365 | Protein ID | WP_000558166.1 |
| Coordinates | 4627922..4628233 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | L8I56_RS22370 | Protein ID | WP_001259010.1 |
| Coordinates | 4628230..4628676 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L8I56_RS22335 (4623580) | 4623580..4624482 | + | 903 | WP_000331361.1 | formate dehydrogenase subunit beta | - |
| L8I56_RS22340 (4624479) | 4624479..4625114 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
| L8I56_RS22345 (4625111) | 4625111..4626040 | + | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
| L8I56_RS22350 (4626087) | 4626087..4626377 | - | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | - |
| L8I56_RS22355 (4626378) | 4626378..4626689 | - | 312 | WP_001159632.1 | cytotoxic translational repressor of toxin-antitoxin stability system | - |
| L8I56_RS22360 (4626907) | 4626907..4627836 | + | 930 | WP_001127699.1 | alpha/beta hydrolase | - |
| L8I56_RS22365 (4627922) | 4627922..4628233 | + | 312 | WP_000558166.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| L8I56_RS22370 (4628230) | 4628230..4628676 | + | 447 | WP_001259010.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| L8I56_RS22375 (4628691) | 4628691..4629632 | - | 942 | WP_001537951.1 | fatty acid biosynthesis protein FabY | - |
| L8I56_RS22380 (4629677) | 4629677..4630114 | - | 438 | WP_000560969.1 | D-aminoacyl-tRNA deacylase | - |
| L8I56_RS22385 (4630111) | 4630111..4630983 | - | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
| L8I56_RS22390 (4630977) | 4630977..4631576 | - | 600 | WP_000965698.1 | glucose-1-phosphatase | - |
| L8I56_RS22395 (4631767) | 4631767..4632570 | - | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| L8I56_RS22400 (4632604) | 4632604..4633500 | - | 897 | WP_001537950.1 | sugar kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12432.40 Da Isoelectric Point: 9.5334
>T234971 WP_000558166.1 NZ_CP091878:4627922-4628233 [Salmonella enterica subsp. enterica serovar Tennessee]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
Download Length: 312 bp
>T234971 NZ_LR134161:4250077-4250355 [Yersinia enterocolitica subsp. enterocolitica]
ATGATAAAAAGTTGGAAACACAAAGGACTGCAACGCTTCTTTGAAACAGGTTCTGCCGCGGGCATTAATCCCCAGCATGT
TAAGCGAATTCGAGACCGCTTGCGATTTATCGACCTGGCGGAAACGATTGAGGATGTCAATGTTGCCGGATACAAGCTCC
ATCCGTTACAAGGTGAAAGAGAAGGGATCTGGTCAGTAACAGTAAGCGGAAATTGGCGCATTACATTCGAGTTTACCGCT
GGAGATGCGTTTATTCTTAACTACGAGGACTACCACTAA
ATGATAAAAAGTTGGAAACACAAAGGACTGCAACGCTTCTTTGAAACAGGTTCTGCCGCGGGCATTAATCCCCAGCATGT
TAAGCGAATTCGAGACCGCTTGCGATTTATCGACCTGGCGGAAACGATTGAGGATGTCAATGTTGCCGGATACAAGCTCC
ATCCGTTACAAGGTGAAAGAGAAGGGATCTGGTCAGTAACAGTAAGCGGAAATTGGCGCATTACATTCGAGTTTACCGCT
GGAGATGCGTTTATTCTTAACTACGAGGACTACCACTAA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16735.03 Da Isoelectric Point: 6.0016
>AT234971 WP_001259010.1 NZ_CP091878:4628230-4628676 [Salmonella enterica subsp. enterica serovar Tennessee]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEETPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEETPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT234971 NZ_LR134161:4250355-4250660 [Yersinia enterocolitica subsp. enterocolitica]
ATGAAAATGCATAATCCCCCACATCCAGGGGAAATGATTGAAGGAATCCTCGAAGATTTGGGTCTAGGGATAAGGGAGTT
TGCCAGGGCATTAAACGTGTCACCTTCAACGGTACAACGGCTGGTTGCCTGTAAGGCGGCAATTTCACCGGAAATGGCGG
TAAAACTGGCCGCGGTTCTGGGAAGTACCCCAGCAATGTGGCTCCGCCTCCAGGCCGCTTATGACCTGGGAAAAGCAGAA
GAGAATGTTGATGTATCCAATCTGACTAAACTGTACAAACCGGATCCAATATCGCTGCATAGTTGA
ATGAAAATGCATAATCCCCCACATCCAGGGGAAATGATTGAAGGAATCCTCGAAGATTTGGGTCTAGGGATAAGGGAGTT
TGCCAGGGCATTAAACGTGTCACCTTCAACGGTACAACGGCTGGTTGCCTGTAAGGCGGCAATTTCACCGGAAATGGCGG
TAAAACTGGCCGCGGTTCTGGGAAGTACCCCAGCAATGTGGCTCCGCCTCCAGGCCGCTTATGACCTGGGAAAAGCAGAA
GAGAATGTTGATGTATCCAATCTGACTAAACTGTACAAACCGGATCCAATATCGCTGCATAGTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|