Detailed information of TA system TA234970

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4626087..4626689
• Replicon: chromosome
• Accession: NZ_CP091878
• Organism: Salmonella enterica subsp. enterica serovar Tennessee strain 21-SA00318-0

Toxin (Protein)

• Gene name: higB
• Uniprot ID: V7IUJ1
• Locus tag: L8I56_RS22355
• Protein ID: WP_001159632.1
• Coordinates: 4626378..4626689 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: L8I56_RS22350
• Protein ID: WP_000362050.1
• Coordinates: 4626087..4626377 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L8I56_RS22335 (4623580)	4623580..4624482	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
L8I56_RS22340 (4624479)	4624479..4625114	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
L8I56_RS22345 (4625111)	4625111..4626040	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
L8I56_RS22350 (4626087)	4626087..4626377	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
L8I56_RS22355 (4626378)	4626378..4626689	-	312	WP_001159632.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
L8I56_RS22360 (4626907)	4626907..4627836	+	930	WP_001127699.1	alpha/beta hydrolase	-
L8I56_RS22365 (4627922)	4627922..4628233	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
L8I56_RS22370 (4628230)	4628230..4628676	+	447	WP_001259010.1	type II toxin-antitoxin system HigA family antitoxin	-
L8I56_RS22375 (4628691)	4628691..4629632	-	942	WP_001537951.1	fatty acid biosynthesis protein FabY	-
L8I56_RS22380 (4629677)	4629677..4630114	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
L8I56_RS22385 (4630111)	4630111..4630983	-	873	WP_000921423.1	virulence factor BrkB family protein	-
L8I56_RS22390 (4630977)	4630977..4631576	-	600	WP_000965698.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12342.27 Da
• Isoelectric Point: 9.4460

>T234970 WP_001159632.1 NZ_CP091878:c4626689-4626378 [Salmonella enterica subsp. enterica serovar Tennessee]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T234970 NZ_LR134161:3598258-3598461 [Yersinia enterocolitica subsp. enterocolitica]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATTGATACATTGGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGACGATGAGCTGGAATTGTTTTACTCAGCAGCAGACCACCGCTTAGCTGAACTCACAATGAATAAAC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT234970 WP_000362050.1 NZ_CP091878:c4626377-4626087 [Salmonella enterica subsp. enterica serovar Tennessee]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT234970 NZ_LR134161:3597843-3598211 [Yersinia enterocolitica subsp. enterocolitica]
ATGGATGAGTACTCACCTAAGCGGCATGACGTTGCCCAATTGAAGTTCCTGTGCGAGAGTTTGTATGATGAAGGCATTGC
TACCCTTGGTGATAGCCATCATGGCTGGGTAAATGATCCAACTTCAGCCGTAAACCTGCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGACGGCGACCTTTCAGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTACGGAATCAATGATCCGGAATTGCAGCGCTGGCAAAAAACTAAAGAGCGTTT
ATTCAGACTTTTCTCAGGGGAATACATCTGTACCCTGATGAAAACTTAG

Structures

Toxin

• AlphaFold DB: A0A4U7VQ31