Detailed information of TA system TA234942

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 799575..799913
• Replicon: chromosome
• Accession: NZ_CP091876
• Organism: Staphylococcus aureus strain FRI-1169

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: MAK06_RS04130
• Protein ID: WP_011447039.1
• Coordinates: 799575..799751 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	799739..799913 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MAK06_RS04110	794810..798595	+	3786	WP_000582170.1	phage tail spike protein	-
MAK06_RS04115	798585..798737	+	153	WP_001153681.1	hypothetical protein	-
MAK06_RS04120	798784..799071	+	288	WP_001040261.1	hypothetical protein	-
MAK06_RS04125	799129..799425	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
MAK06_RS04130	799575..799751	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	799739..799913	-	175	-	-	Antitoxin
MAK06_RS04140	799963..800217	+	255	WP_000611512.1	phage holin	-
MAK06_RS04145	800229..800984	+	756	WP_000861038.1	CHAP domain-containing protein	-
MAK06_RS04150	801175..801666	+	492	WP_000919350.1	staphylokinase	-
MAK06_RS04155	802316..802651	+	336	Protein_817	SH3 domain-containing protein	-
MAK06_RS04160	802746..803195	-	450	WP_000727651.1	chemotaxis-inhibiting protein CHIPS	-
MAK06_RS04165	803879..804229	+	351	WP_000702262.1	complement inhibitor SCIN-A	-
MAK06_RS04170	804282..804542	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sak / chp / scn	744170..804229	60059

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T234942 WP_011447039.1 NZ_CP091876:799575-799751 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T234942 NZ_LR134152:854796-855203 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT234942 NZ_CP091876:c799913-799739 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin