Detailed information of TA system TA234937

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 623773..624052
• Replicon: chromosome
• Accession: NZ_CP091876
• Organism: Staphylococcus aureus strain FRI-1169

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: MAK06_RS03130
• Protein ID: WP_001802298.1
• Coordinates: 623773..623877 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	623873..624052 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MAK06_RS03100	619157..619939	+	783	WP_000908176.1	ABC transporter ATP-binding protein	-
MAK06_RS03105	620007..620864	+	858	WP_000370924.1	HAD family hydrolase	-
MAK06_RS03110	621096..621280	-	185	Protein_613	exotoxin	-
MAK06_RS03115	621569..621661	-	93	WP_001790138.1	hypothetical protein	-
MAK06_RS03120	621950..623086	+	1137	WP_000115564.1	SAP domain-containing protein	-
MAK06_RS03125	623129..623612	+	484	Protein_616	recombinase family protein	-
MAK06_RS03130	623773..623877	+	105	WP_001802298.1	hypothetical protein	Toxin
-	623873..624052	-	180	-	-	Antitoxin
MAK06_RS03140	624377..625468	-	1092	WP_000495671.1	lytic regulatory protein	-
MAK06_RS03145	625734..626714	-	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
MAK06_RS03150	626716..627036	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
MAK06_RS03155	627188..627853	+	666	WP_001024094.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T234937 WP_001802298.1 NZ_CP091876:623773-623877 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T234937 NZ_LR134151:c4707616-4707335 [Serratia plymuthica]
ATGAGCTATAATCTTAAATTCGAGAAACGTGCCCTGAAAGAATGGCAAAAATTGGGGCATCCTATCCGGGAACAATTGAA
AAAGAAGCTGGCGGAGCGGTTGGAGAATCCGCATGTGCCAGCTTCACGGCTCAGTGGCCGCAGTAATCGCTACAAGATTA
AATTGCGTTCATCCGGCTACCGGCTGGTTTATGAAGTTAATGATACTGAAGTCATTTTGTTAGTTATTGCAGTAGGAAAA
CGGGCAGGGGATGAAGTCTATTCAATTGCCGATAAACGATAG

Antitoxin

Nucleotide

• Length: 180 bp

>AT234937 NZ_CP091876:c624052-623873 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTC
AAAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin