Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 345179..345696 | Replicon | chromosome |
| Accession | NZ_CP091876 | ||
| Organism | Staphylococcus aureus strain FRI-1169 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | T1YC79 |
| Locus tag | MAK06_RS01670 | Protein ID | WP_000113262.1 |
| Coordinates | 345430..345696 (+) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | MAK06_RS01665 | Protein ID | WP_000584499.1 |
| Coordinates | 345179..345430 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MAK06_RS01635 (340877) | 340877..341596 | + | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
| MAK06_RS01640 (341593) | 341593..342324 | + | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| MAK06_RS01645 (342421) | 342421..343671 | - | 1251 | WP_001012222.1 | FemA/FemB family glycyltransferase FmhA | - |
| MAK06_RS01650 (343926) | 343926..344288 | + | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| MAK06_RS01655 (344307) | 344307..344906 | + | 600 | WP_000162813.1 | DsbA family protein | - |
| MAK06_RS01660 (344913) | 344913..345014 | + | 102 | WP_001791744.1 | hypothetical protein | - |
| MAK06_RS01665 (345179) | 345179..345430 | + | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| MAK06_RS01670 (345430) | 345430..345696 | + | 267 | WP_000113262.1 | Txe/YoeB family addiction module toxin | Toxin |
| MAK06_RS01675 (345731) | 345731..345802 | + | 72 | Protein_334 | hypothetical protein | - |
| MAK06_RS01680 (345991) | 345991..347541 | + | 1551 | WP_000727762.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| MAK06_RS01685 (347727) | 347727..348194 | + | 468 | WP_000153344.1 | SRPBCC domain-containing protein | - |
| MAK06_RS01690 (348278) | 348278..348460 | + | 183 | WP_000230294.1 | hypothetical protein | - |
| MAK06_RS01695 (348677) | 348677..349501 | + | 825 | WP_000572040.1 | formate/nitrite transporter family protein | - |
| MAK06_RS01700 (349734) | 349734..350270 | + | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.95 Da Isoelectric Point: 9.9143
>T234935 WP_000113262.1 NZ_CP091876:345430-345696 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T234935 NZ_LR134151:4221081-4221437 [Serratia plymuthica]
ATGTGGCAGGTCATAACCGTCGAACGATTCGACGACTGGTTTTTATCACTGAACGACGATGAACAAAAAAGCCTGTTGGC
AGGAATATTCAAATTGCAGGAATTCGGCCCGCTGTTGGCGCGTCCGCATGCCGACACTCTGCATTTTTCAGGCTCAATAA
GGCATCTTAAAGAGCTGCGCATTCAGCACCGCGGCCGCCCGTTTCGAGTATTTTTCGCCTTTGATCCGCAACGGCAGGCG
GTACTGCTATGCGGTGGCGATAAAACCGGCGATAAAACCGGCGATAAACGCTTTTACCAGCGCCTGTTGCCTATCGCCGC
CATGGAATTTTCACATTATCTGGCAACCCAGAGGTAA
ATGTGGCAGGTCATAACCGTCGAACGATTCGACGACTGGTTTTTATCACTGAACGACGATGAACAAAAAAGCCTGTTGGC
AGGAATATTCAAATTGCAGGAATTCGGCCCGCTGTTGGCGCGTCCGCATGCCGACACTCTGCATTTTTCAGGCTCAATAA
GGCATCTTAAAGAGCTGCGCATTCAGCACCGCGGCCGCCCGTTTCGAGTATTTTTCGCCTTTGATCCGCAACGGCAGGCG
GTACTGCTATGCGGTGGCGATAAAACCGGCGATAAAACCGGCGATAAACGCTTTTACCAGCGCCTGTTGCCTATCGCCGC
CATGGAATTTTCACATTATCTGGCAACCCAGAGGTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT234935 WP_000584499.1 NZ_CP091876:345179-345430 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT234935 NZ_LR134151:4221443-4221745 [Serratia plymuthica]
ATGGCCAAGCCTTTATCAAATCTGATCGATAAACTCGATCCCACCGTCGTTGCGGCAGCCCGGCAAAAGGCGGAGAAAGA
AATTTTTGAACTGCGTCTGGCGATGCTGCGGGAAGAACTTGCGGTGTCTCAGGTCGAGCTGGCGAAACGGCTTGGCATCA
GCCAGCCGTCGGTCGCTAATCTGGAAAAGCGCGGTAGCGAAATCAAACTCTCTTCACTGAAACGCTACATTGAAGCCATG
GGCGGCACGCTTTCGTTAGAGGTTGAGCTGCCCAACGGCCAGCATCGGCGGATGACACTCTGA
ATGGCCAAGCCTTTATCAAATCTGATCGATAAACTCGATCCCACCGTCGTTGCGGCAGCCCGGCAAAAGGCGGAGAAAGA
AATTTTTGAACTGCGTCTGGCGATGCTGCGGGAAGAACTTGCGGTGTCTCAGGTCGAGCTGGCGAAACGGCTTGGCATCA
GCCAGCCGTCGGTCGCTAATCTGGAAAAGCGCGGTAGCGAAATCAAACTCTCTTCACTGAAACGCTACATTGAAGCCATG
GGCGGCACGCTTTCGTTAGAGGTTGAGCTGCCCAACGGCCAGCATCGGCGGATGACACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|